Functional interaction between receptors for dopamine antagonists and GABA central receptors

M. Trabucchi; S. Govoni; G. C. Tonon; P. F. Spano

doi:10.1016/0024-3205(78)90103-0

Functional interaction between receptors for dopamine antagonists and GABA central receptors

M. Trabucchi, S. Govoni, G. C. Tonon, P. F. Spano

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The plasticity of GABA receptors has been demonstrated after different pharmacological treatments. Intrastriatal kainic acid injection induces a significant increase of ³H -GABA and ³H -spiroperidol binding both in striatum and substantia nigra. On the other hand, a single injection of hal operidol decreases in a dose dependent manner ³H -GABA binding both in striatum and cerebellum but not in substantia nigra. Other neuroleptics such as chlorpromazine and sulpiride induce the same changes in ³H-GABA binding, while clozapine tend to increase the GABA radioreceptor binding.

Original language	English
Pages (from-to)	1751-1756
Number of pages	6
Journal	Life Sciences
Volume	23
Issue number	17-18
DOIs	https://doi.org/10.1016/0024-3205(78)90103-0
Publication status	Published - Oct 30 1978

ASJC Scopus subject areas

Pharmacology

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title = "Functional interaction between receptors for dopamine antagonists and GABA central receptors",

abstract = "The plasticity of GABA receptors has been demonstrated after different pharmacological treatments. Intrastriatal kainic acid injection induces a significant increase of 3H -GABA and 3H -spiroperidol binding both in striatum and substantia nigra. On the other hand, a single injection of hal operidol decreases in a dose dependent manner 3H -GABA binding both in striatum and cerebellum but not in substantia nigra. Other neuroleptics such as chlorpromazine and sulpiride induce the same changes in 3H-GABA binding, while clozapine tend to increase the GABA radioreceptor binding.",

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AU - Trabucchi, M.

AU - Govoni, S.

AU - Tonon, G. C.

AU - Spano, P. F.

PY - 1978/10/30

Y1 - 1978/10/30

N2 - The plasticity of GABA receptors has been demonstrated after different pharmacological treatments. Intrastriatal kainic acid injection induces a significant increase of 3H -GABA and 3H -spiroperidol binding both in striatum and substantia nigra. On the other hand, a single injection of hal operidol decreases in a dose dependent manner 3H -GABA binding both in striatum and cerebellum but not in substantia nigra. Other neuroleptics such as chlorpromazine and sulpiride induce the same changes in 3H-GABA binding, while clozapine tend to increase the GABA radioreceptor binding.

AB - The plasticity of GABA receptors has been demonstrated after different pharmacological treatments. Intrastriatal kainic acid injection induces a significant increase of 3H -GABA and 3H -spiroperidol binding both in striatum and substantia nigra. On the other hand, a single injection of hal operidol decreases in a dose dependent manner 3H -GABA binding both in striatum and cerebellum but not in substantia nigra. Other neuroleptics such as chlorpromazine and sulpiride induce the same changes in 3H-GABA binding, while clozapine tend to increase the GABA radioreceptor binding.

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JO - Life Sciences

JF - Life Sciences

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Functional interaction between receptors for dopamine antagonists and GABA central receptors

Abstract

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