Functional interaction between receptors for dopamine antagonists and GABA central receptors

M. Trabucchi, S. Govoni, G. C. Tonon, P. F. Spano

Research output: Contribution to journalArticlepeer-review

Abstract

The plasticity of GABA receptors has been demonstrated after different pharmacological treatments. Intrastriatal kainic acid injection induces a significant increase of 3H -GABA and 3H -spiroperidol binding both in striatum and substantia nigra. On the other hand, a single injection of hal operidol decreases in a dose dependent manner 3H -GABA binding both in striatum and cerebellum but not in substantia nigra. Other neuroleptics such as chlorpromazine and sulpiride induce the same changes in 3H-GABA binding, while clozapine tend to increase the GABA radioreceptor binding.

Original languageEnglish
Pages (from-to)1751-1756
Number of pages6
JournalLife Sciences
Volume23
Issue number17-18
DOIs
Publication statusPublished - Oct 30 1978

ASJC Scopus subject areas

  • Pharmacology

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