Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation

Chiara Naro, Livia Pellegrini, Ariane Jolly, Donatella Farini, Eleonora Cesari, Pamela Bielli, Pierre de la Grange, Claudio Sette

Research output: Contribution to journalArticlepeer-review

Abstract

Naro et al. show that Sam68 regulates an extensive splicing program during male germ cell differentiation. Sam68 primarily regulates alternative last exon selection in genes with functional relevance for spermatogenesis by preventing premature transcript termination and conferring tissue specificity to the U1snRNP telescripting activity.

Original languageEnglish
Pages (from-to)2929-2941.e5
JournalCell Reports
Volume26
Issue number11
DOIs
Publication statusPublished - Mar 12 2019

Keywords

  • alternative polyadenylation
  • alternative splicing
  • germ cell differentiation
  • male fertility
  • Sam68
  • spermatogenesis
  • U1snRNP

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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