Functional Magnetic Resonance Imaging of Inhibitory Control Reveals Decreased Blood Oxygen Level Dependent Effect in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Gioele Gavazzi, Stefano Orsolini, Emilia Salvadori, Andrea Bianchi, Arianna Rossi, Ida Donnini, Valentina Rinnoci, Francesca Pescini, Stefano Diciotti, Maria Pia Viggiano, Mario Mascalchi, Leonardo Pantoni

Research output: Contribution to journalArticle

Abstract

Background and Purpose- Small-vessel damage in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is associated with impaired vascular constriction and dilation. We used a functional magnetic resonance imaging task with an event-related design of stimulus to explore the anticipated abnormally decreased blood oxygen level dependent effect in CADASIL. Methods- Twenty-one CADASIL patients and 16 healthy controls performed a Go/No-go task exploring reactive and proactive phases of inhibition control in a 3-T magnet. Results- Error number and reaction times were not different between patients and controls. Analysis of the reactive inhibition (No-go/baseline contrast) did not show clusters of lower or higher blood oxygen level dependent effect in patients or controls. Analysis of the proactive inhibition (alertness contrast) in CADASIL patients revealed a lower blood oxygen level dependent effect in the alerting network (anterior cingulate cortex and insula, thalamus), lower brain stem and left cerebellar hemisphere (crus I) that is involved in executive functions. Conclusions- In CADASIL patients, an event-related Go/No-go task reveals a lower blood oxygen level dependent effect in the alerting network and areas involved in executive functions possibly reflecting the altered hemodynamic response secondary to small-vessel changes. Our observation extends the role of MR in demonstrating one of the fundamental pathophysiological changes of CADASIL.

Original languageEnglish
Pages (from-to)STROKEAHA118022923
JournalStroke
DOIs
Publication statusE-pub ahead of print - Dec 10 2018

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CADASIL
Magnetic Resonance Imaging
Oxygen
Proactive Inhibition
Executive Function
Reactive Inhibition
Magnets
Gyrus Cinguli
Thalamus
Constriction
Brain Stem
Reaction Time
Blood Vessels
Dilatation
Hemodynamics
Observation

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Functional Magnetic Resonance Imaging of Inhibitory Control Reveals Decreased Blood Oxygen Level Dependent Effect in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy. / Gavazzi, Gioele; Orsolini, Stefano; Salvadori, Emilia; Bianchi, Andrea; Rossi, Arianna; Donnini, Ida; Rinnoci, Valentina; Pescini, Francesca; Diciotti, Stefano; Viggiano, Maria Pia; Mascalchi, Mario; Pantoni, Leonardo.

In: Stroke, 10.12.2018, p. STROKEAHA118022923.

Research output: Contribution to journalArticle

Gavazzi, Gioele ; Orsolini, Stefano ; Salvadori, Emilia ; Bianchi, Andrea ; Rossi, Arianna ; Donnini, Ida ; Rinnoci, Valentina ; Pescini, Francesca ; Diciotti, Stefano ; Viggiano, Maria Pia ; Mascalchi, Mario ; Pantoni, Leonardo. / Functional Magnetic Resonance Imaging of Inhibitory Control Reveals Decreased Blood Oxygen Level Dependent Effect in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy. In: Stroke. 2018 ; pp. STROKEAHA118022923.
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abstract = "Background and Purpose- Small-vessel damage in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is associated with impaired vascular constriction and dilation. We used a functional magnetic resonance imaging task with an event-related design of stimulus to explore the anticipated abnormally decreased blood oxygen level dependent effect in CADASIL. Methods- Twenty-one CADASIL patients and 16 healthy controls performed a Go/No-go task exploring reactive and proactive phases of inhibition control in a 3-T magnet. Results- Error number and reaction times were not different between patients and controls. Analysis of the reactive inhibition (No-go/baseline contrast) did not show clusters of lower or higher blood oxygen level dependent effect in patients or controls. Analysis of the proactive inhibition (alertness contrast) in CADASIL patients revealed a lower blood oxygen level dependent effect in the alerting network (anterior cingulate cortex and insula, thalamus), lower brain stem and left cerebellar hemisphere (crus I) that is involved in executive functions. Conclusions- In CADASIL patients, an event-related Go/No-go task reveals a lower blood oxygen level dependent effect in the alerting network and areas involved in executive functions possibly reflecting the altered hemodynamic response secondary to small-vessel changes. Our observation extends the role of MR in demonstrating one of the fundamental pathophysiological changes of CADASIL.",
author = "Gioele Gavazzi and Stefano Orsolini and Emilia Salvadori and Andrea Bianchi and Arianna Rossi and Ida Donnini and Valentina Rinnoci and Francesca Pescini and Stefano Diciotti and Viggiano, {Maria Pia} and Mario Mascalchi and Leonardo Pantoni",
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AU - Gavazzi, Gioele

AU - Orsolini, Stefano

AU - Salvadori, Emilia

AU - Bianchi, Andrea

AU - Rossi, Arianna

AU - Donnini, Ida

AU - Rinnoci, Valentina

AU - Pescini, Francesca

AU - Diciotti, Stefano

AU - Viggiano, Maria Pia

AU - Mascalchi, Mario

AU - Pantoni, Leonardo

PY - 2018/12/10

Y1 - 2018/12/10

N2 - Background and Purpose- Small-vessel damage in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is associated with impaired vascular constriction and dilation. We used a functional magnetic resonance imaging task with an event-related design of stimulus to explore the anticipated abnormally decreased blood oxygen level dependent effect in CADASIL. Methods- Twenty-one CADASIL patients and 16 healthy controls performed a Go/No-go task exploring reactive and proactive phases of inhibition control in a 3-T magnet. Results- Error number and reaction times were not different between patients and controls. Analysis of the reactive inhibition (No-go/baseline contrast) did not show clusters of lower or higher blood oxygen level dependent effect in patients or controls. Analysis of the proactive inhibition (alertness contrast) in CADASIL patients revealed a lower blood oxygen level dependent effect in the alerting network (anterior cingulate cortex and insula, thalamus), lower brain stem and left cerebellar hemisphere (crus I) that is involved in executive functions. Conclusions- In CADASIL patients, an event-related Go/No-go task reveals a lower blood oxygen level dependent effect in the alerting network and areas involved in executive functions possibly reflecting the altered hemodynamic response secondary to small-vessel changes. Our observation extends the role of MR in demonstrating one of the fundamental pathophysiological changes of CADASIL.

AB - Background and Purpose- Small-vessel damage in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is associated with impaired vascular constriction and dilation. We used a functional magnetic resonance imaging task with an event-related design of stimulus to explore the anticipated abnormally decreased blood oxygen level dependent effect in CADASIL. Methods- Twenty-one CADASIL patients and 16 healthy controls performed a Go/No-go task exploring reactive and proactive phases of inhibition control in a 3-T magnet. Results- Error number and reaction times were not different between patients and controls. Analysis of the reactive inhibition (No-go/baseline contrast) did not show clusters of lower or higher blood oxygen level dependent effect in patients or controls. Analysis of the proactive inhibition (alertness contrast) in CADASIL patients revealed a lower blood oxygen level dependent effect in the alerting network (anterior cingulate cortex and insula, thalamus), lower brain stem and left cerebellar hemisphere (crus I) that is involved in executive functions. Conclusions- In CADASIL patients, an event-related Go/No-go task reveals a lower blood oxygen level dependent effect in the alerting network and areas involved in executive functions possibly reflecting the altered hemodynamic response secondary to small-vessel changes. Our observation extends the role of MR in demonstrating one of the fundamental pathophysiological changes of CADASIL.

U2 - 10.1161/STROKEAHA.118.022923

DO - 10.1161/STROKEAHA.118.022923

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