TY - JOUR
T1 - Functional motor disorders associated with other neurological diseases
T2 - Beyond the boundaries of "organic" neurology
AU - Tinazzi, Michele
AU - Geroin, Christian
AU - Erro, Roberto
AU - Marcuzzo, Enrico
AU - Cuoco, Sofia
AU - Ceravolo, Roberto
AU - Mazzucchi, Sonia
AU - Pilotto, Andrea
AU - Padovani, Alessandro
AU - Michele Romito, Luigi
AU - Eleopra, Roberto
AU - Zappia, Mario
AU - Nicoletti, Alessandra
AU - Dallocchio, Carlo
AU - Arbasino, Carla
AU - Bono, Francesco
AU - Pascarella, Angelo
AU - Demartini, Benedetta
AU - Gambini, Orsola
AU - Modugno, Nicola
AU - Olivola, Enrica
AU - Bonanni, Laura
AU - Antelmi, Elena
AU - Zanolin, Elisabetta
AU - Albanese, Alberto
AU - Ferrazzano, Gina
AU - de Micco, Rosa
AU - Lopiano, Leonardo
AU - Calandra-Buonaura, Giovanna
AU - Petracca, Martina
AU - Esposito, Marcello
AU - Pisani, Antonio
AU - Manganotti, Paolo
AU - Stocchi, Fabrizio
AU - Coletti Moja, Mario
AU - Antonini, Angelo
AU - Ercoli, Tommaso
AU - Morgante, Francesca
N1 - This article is protected by copyright. All rights reserved.
PY - 2020/12/9
Y1 - 2020/12/9
N2 - OBJECTIVE: 1) to describe the clinical manifestations of functional motor disorders (FMDs) coexisting with other neurological diseases ("comorbid-FMDs"); 2) to compare comorbid-FMDs to FMDs not overlapping with other neurological diseases ("pure FMDs").METHODS: For this multicenter observational study, we enrolled outpatients with a definite diagnosis of FMDs attending 25 tertiary movement disorders centers in Italy. Each subject with FMDs underwent a detailed clinical assessment including screening for other associated neurological conditions. Groups comparisons (comorbid-FMDs versus pure-FMDs) were performed in order to compare demographical and clinical variables. Logistic regression models were created to estimate adjusted odds ratio (OR; 95% confidence interval) of comorbid-FMDs (dependent variable) in relation to sociodemographic and clinical characteristics (independent variables).RESULTS: Out of 410 FMDs, 21.7% (n=89) of patients had comorbid-FMDs. The most frequent coexisting neurological diseases were migraine, cerebrovascular disease and parkinsonism. In the majority of cases (86.5%) FMDs appeared after the diagnosis of neurological disease. Patients with comorbid-FMDs were older, had more frequent tremor, non-neurological comorbidities, paroxysmal non-epileptic seizures, major depressive disorders, and benzodiazepine intake. Multivariate regression analysis showed that diagnosis of comorbid-FMDs was more likely associated with longer time lag to reach the final diagnosis of FMDs, presence of tremor and non-neurological comorbidities.CONCLUSIONS: Our findings highlight the need of a prompt diagnosis of FMDs, given their relatively high frequency of associated neurological and non-neurological diseases.
AB - OBJECTIVE: 1) to describe the clinical manifestations of functional motor disorders (FMDs) coexisting with other neurological diseases ("comorbid-FMDs"); 2) to compare comorbid-FMDs to FMDs not overlapping with other neurological diseases ("pure FMDs").METHODS: For this multicenter observational study, we enrolled outpatients with a definite diagnosis of FMDs attending 25 tertiary movement disorders centers in Italy. Each subject with FMDs underwent a detailed clinical assessment including screening for other associated neurological conditions. Groups comparisons (comorbid-FMDs versus pure-FMDs) were performed in order to compare demographical and clinical variables. Logistic regression models were created to estimate adjusted odds ratio (OR; 95% confidence interval) of comorbid-FMDs (dependent variable) in relation to sociodemographic and clinical characteristics (independent variables).RESULTS: Out of 410 FMDs, 21.7% (n=89) of patients had comorbid-FMDs. The most frequent coexisting neurological diseases were migraine, cerebrovascular disease and parkinsonism. In the majority of cases (86.5%) FMDs appeared after the diagnosis of neurological disease. Patients with comorbid-FMDs were older, had more frequent tremor, non-neurological comorbidities, paroxysmal non-epileptic seizures, major depressive disorders, and benzodiazepine intake. Multivariate regression analysis showed that diagnosis of comorbid-FMDs was more likely associated with longer time lag to reach the final diagnosis of FMDs, presence of tremor and non-neurological comorbidities.CONCLUSIONS: Our findings highlight the need of a prompt diagnosis of FMDs, given their relatively high frequency of associated neurological and non-neurological diseases.
U2 - 10.1111/ene.14674
DO - 10.1111/ene.14674
M3 - Article
JO - Eur. J. Neurol.
JF - Eur. J. Neurol.
SN - 1351-5101
ER -