Functional MR Imaging in Multiple Sclerosis

Research output: Contribution to journalArticlepeer-review


A variable effectiveness of reparative and recovery mechanisms following tissue damage is among the factors that might contribute to explaining resolution of symptoms and maintenance of a normal level of function in patients who have multiple sclerosis (MS). The application of functional MR imaging in MS has shown that cortical changes do occur after white matter injury and that these changes can contribute to limiting the clinical outcome of such damage. Conversely, the failure or exhaustion of the adaptive properties of the cerebral cortex with increasing disease duration and burden might be among the factors responsible for the accumulation of fixed neurologic deficits in patients who have MS.

Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalNeuroimaging Clinics of North America
Issue number1
Publication statusPublished - Feb 2009


  • Adaptation
  • Cognition
  • Functional magnetic resonance imaging
  • Motor system
  • Multiple sclerosis
  • Visual system

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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