Functional MRI changes in the central motor system in myotonic dystrophy type 1

Francesca Caramia, Caterina Mainero, Francesca Gragnani, Emanuele Tinelli, Marco Fiorelli, Vanessa Ceschin, Patrizia Pantano, Elisabetta Bucci, Veronica Barra, Luigi Bozzao, Giovanni Antonini

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P

Original languageEnglish
Pages (from-to)226-234
Number of pages9
JournalMagnetic Resonance Imaging
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Myotonic Dystrophy
Magnetic Resonance Imaging
Motor Cortex
Neurology
Central Nervous System
Chemical activation
Parietal Lobe
Thumb
Basal Ganglia
Thalamus
Fingers
Muscle
Hand
Muscles

Keywords

  • Aging
  • Brain
  • CNS
  • FMRI
  • Motor activity
  • Myotonic dystrophy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Caramia, F., Mainero, C., Gragnani, F., Tinelli, E., Fiorelli, M., Ceschin, V., ... Antonini, G. (2010). Functional MRI changes in the central motor system in myotonic dystrophy type 1. Magnetic Resonance Imaging, 28(2), 226-234. https://doi.org/10.1016/j.mri.2009.07.006

Functional MRI changes in the central motor system in myotonic dystrophy type 1. / Caramia, Francesca; Mainero, Caterina; Gragnani, Francesca; Tinelli, Emanuele; Fiorelli, Marco; Ceschin, Vanessa; Pantano, Patrizia; Bucci, Elisabetta; Barra, Veronica; Bozzao, Luigi; Antonini, Giovanni.

In: Magnetic Resonance Imaging, Vol. 28, No. 2, 02.2010, p. 226-234.

Research output: Contribution to journalArticle

Caramia, F, Mainero, C, Gragnani, F, Tinelli, E, Fiorelli, M, Ceschin, V, Pantano, P, Bucci, E, Barra, V, Bozzao, L & Antonini, G 2010, 'Functional MRI changes in the central motor system in myotonic dystrophy type 1', Magnetic Resonance Imaging, vol. 28, no. 2, pp. 226-234. https://doi.org/10.1016/j.mri.2009.07.006
Caramia F, Mainero C, Gragnani F, Tinelli E, Fiorelli M, Ceschin V et al. Functional MRI changes in the central motor system in myotonic dystrophy type 1. Magnetic Resonance Imaging. 2010 Feb;28(2):226-234. https://doi.org/10.1016/j.mri.2009.07.006
Caramia, Francesca ; Mainero, Caterina ; Gragnani, Francesca ; Tinelli, Emanuele ; Fiorelli, Marco ; Ceschin, Vanessa ; Pantano, Patrizia ; Bucci, Elisabetta ; Barra, Veronica ; Bozzao, Luigi ; Antonini, Giovanni. / Functional MRI changes in the central motor system in myotonic dystrophy type 1. In: Magnetic Resonance Imaging. 2010 ; Vol. 28, No. 2. pp. 226-234.
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