Functional MRI changes in the central motor system in myotonic dystrophy type 1

Francesca Caramia; Caterina Mainero; Francesca Gragnani; Emanuele Tinelli; Marco Fiorelli; Vanessa Ceschin; Patrizia Pantano; Elisabetta Bucci; Veronica Barra; Luigi Bozzao; Giovanni Antonini

doi:10.1016/j.mri.2009.07.006

Functional MRI changes in the central motor system in myotonic dystrophy type 1

Francesca Caramia, Caterina Mainero, Francesca Gragnani, Emanuele Tinelli, Marco Fiorelli, Vanessa Ceschin, Patrizia Pantano, Elisabetta Bucci, Veronica Barra, Luigi Bozzao, Giovanni Antonini

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Abstract

Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P

Original language	English
Pages (from-to)	226-234
Number of pages	9
Journal	Magnetic Resonance Imaging
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.mri.2009.07.006
Publication status	Published - Feb 2010

Keywords

Aging
Brain
CNS
FMRI
Motor activity
Myotonic dystrophy

ASJC Scopus subject areas

Biophysics
Radiology Nuclear Medicine and imaging
Biomedical Engineering

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10.1016/j.mri.2009.07.006

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title = "Functional MRI changes in the central motor system in myotonic dystrophy type 1",

abstract = "Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P",

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AU - Caramia, Francesca

AU - Mainero, Caterina

AU - Gragnani, Francesca

AU - Tinelli, Emanuele

AU - Fiorelli, Marco

AU - Ceschin, Vanessa

AU - Pantano, Patrizia

AU - Bucci, Elisabetta

AU - Barra, Veronica

AU - Bozzao, Luigi

AU - Antonini, Giovanni

PY - 2010/2

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N2 - Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P

AB - Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P

KW - Aging

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KW - CNS

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KW - Motor activity

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Functional MRI changes in the central motor system in myotonic dystrophy type 1

Abstract

Keywords

ASJC Scopus subject areas

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