Functional MRI changes in the central motor system in myotonic dystrophy type 1

Francesca Caramia; Caterina Mainero; Francesca Gragnani; Emanuele Tinelli; Marco Fiorelli; Vanessa Ceschin; Patrizia Pantano; Elisabetta Bucci; Veronica Barra; Luigi Bozzao; Giovanni Antonini

doi:10.1016/j.mri.2009.07.006

Functional MRI changes in the central motor system in myotonic dystrophy type 1

Francesca Caramia, Caterina Mainero, Francesca Gragnani, Emanuele Tinelli, Marco Fiorelli, Vanessa Ceschin, Patrizia Pantano, Elisabetta Bucci, Veronica Barra, Luigi Bozzao, Giovanni Antonini

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Research output: Contribution to journal › Article › peer-review

Abstract

Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P

Original language	English
Pages (from-to)	226-234
Number of pages	9
Journal	Magnetic Resonance Imaging
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.mri.2009.07.006
Publication status	Published - Feb 2010

Keywords

Aging
Brain
CNS
FMRI
Motor activity
Myotonic dystrophy

ASJC Scopus subject areas

Biophysics
Radiology Nuclear Medicine and imaging
Biomedical Engineering

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10.1016/j.mri.2009.07.006

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Functional MRI changes in the central motor system in myotonic dystrophy type 1. / Caramia, Francesca; Mainero, Caterina; Gragnani, Francesca; Tinelli, Emanuele; Fiorelli, Marco; Ceschin, Vanessa; Pantano, Patrizia; Bucci, Elisabetta; Barra, Veronica; Bozzao, Luigi; Antonini, Giovanni.

In: Magnetic Resonance Imaging, Vol. 28, No. 2, 02.2010, p. 226-234.

Research output: Contribution to journal › Article › peer-review

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AU - Fiorelli, Marco

AU - Ceschin, Vanessa

AU - Pantano, Patrizia

AU - Bucci, Elisabetta

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Functional MRI changes in the central motor system in myotonic dystrophy type 1

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Keywords

ASJC Scopus subject areas

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