Abstract
Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P
| Original language | English |
|---|---|
| Pages (from-to) | 226-234 |
| Number of pages | 9 |
| Journal | Magnetic Resonance Imaging |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
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Keywords
- Aging
- Brain
- CNS
- FMRI
- Motor activity
- Myotonic dystrophy
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
- Biomedical Engineering
Cite this
Functional MRI changes in the central motor system in myotonic dystrophy type 1. / Caramia, Francesca; Mainero, Caterina; Gragnani, Francesca; Tinelli, Emanuele; Fiorelli, Marco; Ceschin, Vanessa; Pantano, Patrizia; Bucci, Elisabetta; Barra, Veronica; Bozzao, Luigi; Antonini, Giovanni.
In: Magnetic Resonance Imaging, Vol. 28, No. 2, 02.2010, p. 226-234.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional MRI changes in the central motor system in myotonic dystrophy type 1
AU - Caramia, Francesca
AU - Mainero, Caterina
AU - Gragnani, Francesca
AU - Tinelli, Emanuele
AU - Fiorelli, Marco
AU - Ceschin, Vanessa
AU - Pantano, Patrizia
AU - Bucci, Elisabetta
AU - Barra, Veronica
AU - Bozzao, Luigi
AU - Antonini, Giovanni
PY - 2010/2
Y1 - 2010/2
N2 - Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P
AB - Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P
KW - Aging
KW - Brain
KW - CNS
KW - FMRI
KW - Motor activity
KW - Myotonic dystrophy
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UR - http://www.scopus.com/inward/citedby.url?scp=77349120749&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2009.07.006
DO - 10.1016/j.mri.2009.07.006
M3 - Article
VL - 28
SP - 226
EP - 234
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 2
ER -