Functional MRI changes in the central motor system in myotonic dystrophy type 1

Francesca Caramia, Caterina Mainero, Francesca Gragnani, Emanuele Tinelli, Marco Fiorelli, Vanessa Ceschin, Patrizia Pantano, Elisabetta Bucci, Veronica Barra, Luigi Bozzao, Giovanni Antonini

Research output: Contribution to journalArticle

Abstract

Myotonic dystrophy type 1 (DM1) is a multisystemic disease involving multiple organ systems including central nervous system (CNS) and muscles. Few studies have focused on the central motor system in DM1, pointing to a subclinical abnormality in the CNS. The aim of our study was to investigate patterns of cerebral activation in DM1 during a motor task using functional MRI (fMRI). Fifteen DM1 patients, aged 20 to 59 years, and 15 controls of comparable age were scanned during a self-paced sequential finger-to-thumb opposition task of their dominant right hand. Functional MRI images were analyzed using SPM99. Patients underwent clinical and genetic assessment; all subjects underwent a conventional MR study. Myotonic dystrophy type 1 patients showed greater activation than controls in bilateral sensorimotor areas and inferior parietal lobules, basal ganglia and thalami, in the ipsilateral premotor area, insula and supplementary motor area (corrected P

Original languageEnglish
Pages (from-to)226-234
Number of pages9
JournalMagnetic Resonance Imaging
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Aging
  • Brain
  • CNS
  • FMRI
  • Motor activity
  • Myotonic dystrophy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

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    Caramia, F., Mainero, C., Gragnani, F., Tinelli, E., Fiorelli, M., Ceschin, V., Pantano, P., Bucci, E., Barra, V., Bozzao, L., & Antonini, G. (2010). Functional MRI changes in the central motor system in myotonic dystrophy type 1. Magnetic Resonance Imaging, 28(2), 226-234. https://doi.org/10.1016/j.mri.2009.07.006