Functional MRI of the human brain with GRASE-based BOLD contrast

Jorge Jovicich, David G. Norris

Research output: Contribution to journalArticlepeer-review


The application of T2*-weighted gradient and spin-echo (GRASE) imaging was investigated as a method for blood oxygenation level-dependent (BOLD)- based functional magnetic resonance imaging (fMRI). The displaced-echo method was implemented to produce single-shot T2*-weighted GRASE images. This technique removes the requirement that the Carr-Purcell Meiboom-Gill (CPMG) condition be fulfilled. T2*-weighted GRASE images that are free from interference artifacts can thus be obtained, hence allowing the possibility of using single-shot GRASE for BOLD-based functional imaging. The method was demonstrated at 3 T and gave robust and reproducible activation-induced signal changes.

Original languageEnglish
Pages (from-to)871-876
Number of pages6
JournalMagnetic Resonance in Medicine
Issue number5
Publication statusPublished - 1999


  • Displaced-echo
  • Functional MRI
  • GRASE imaging
  • Template interactive phase encoding

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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