Functional neuroimaging and headache pathophysiology: New findings and new prospects

M. Leone, A. Proietti Cecchini, E. Mea, M. Curone, V. Tullo, G. Casucci, V. Bonavita, G. Bussone

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the last ten years pathophysiology of primary headaches has received new insights from neuroimaging studies. Positron emission tomography (PET) showed activation of specific brain structures, brainstem in migraine and hypothalamic grey in trigeminal autonomic cephalalgias. This brain activation suggests it may intervene both in a permissive or triggering manner and as a response to pain driven by the first division of the trigeminal nerve. Voxel-based morphometry has suggested that there is a correlation between the brain area activated specifically in acute cluster headache - the posterior hypothalamic grey matter - and an increase in grey matter in the same region. New insights into mechanisms of head pain have emerged thanks to neuroimaging obtained in experimentally induced headaches, and during peripheral and central neurostimulation.

Original languageEnglish
JournalNeurological Sciences
Volume28
Issue numberSUPPL. 2
DOIs
Publication statusPublished - May 2007

Fingerprint

Functional Neuroimaging
Headache
Neuroimaging
Trigeminal Autonomic Cephalalgias
Brain
Cluster Headache
Trigeminal Nerve
Migraine Disorders
Positron-Emission Tomography
Brain Stem
Pain
Gray Matter

Keywords

  • Cluster headache
  • Migraine
  • Neuroimaging
  • SUNCT
  • Trigeminal autonomic cephalalgias

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Leone, M., Proietti Cecchini, A., Mea, E., Curone, M., Tullo, V., Casucci, G., ... Bussone, G. (2007). Functional neuroimaging and headache pathophysiology: New findings and new prospects. Neurological Sciences, 28(SUPPL. 2). https://doi.org/10.1007/s10072-007-0761-9

Functional neuroimaging and headache pathophysiology : New findings and new prospects. / Leone, M.; Proietti Cecchini, A.; Mea, E.; Curone, M.; Tullo, V.; Casucci, G.; Bonavita, V.; Bussone, G.

In: Neurological Sciences, Vol. 28, No. SUPPL. 2, 05.2007.

Research output: Contribution to journalArticle

Leone, M, Proietti Cecchini, A, Mea, E, Curone, M, Tullo, V, Casucci, G, Bonavita, V & Bussone, G 2007, 'Functional neuroimaging and headache pathophysiology: New findings and new prospects', Neurological Sciences, vol. 28, no. SUPPL. 2. https://doi.org/10.1007/s10072-007-0761-9
Leone, M. ; Proietti Cecchini, A. ; Mea, E. ; Curone, M. ; Tullo, V. ; Casucci, G. ; Bonavita, V. ; Bussone, G. / Functional neuroimaging and headache pathophysiology : New findings and new prospects. In: Neurological Sciences. 2007 ; Vol. 28, No. SUPPL. 2.
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