Functional neuroimaging of breastfeeding analgesia by multichannel near-infrared spectroscopy

Stefano Bembich, Riccardo Davanzo, Pierpaolo Brovedani, Andrea Clarici, Stefano Massaccesi, Sergio Demarini

Research output: Contribution to journalArticle

Abstract

Background: Newborns perceive pain, and several non-pharmacologic analgesic methods have been used during painful procedures. Activation of the neonatal somatosensory cortex, in association with a painful procedure without analgesia, has been demonstrated by two-channel near-infrared spectroscopy (NIRS). Objectives: To evaluate both cortical and behavioural responses of healthy term newborns to a painful procedure during two non-pharmacologic analgesic interventions, i.e. glucose solution and breastfeeding. Methods: The effects of glucose and breastfeeding on pain-associated neonatal cortical activity were studied in two groups (n = 30) by multichannel NIRS during a heel prick. Cortical activation was identified by variations in oxygenated haemoglobin. Neonatal pain expression was assessed by a validated scale. Results: No significant variations in cortical activity emerged using glucose solution, whereas breastfed newborns showed widespread cortical activation. Breastfed neonates showed significantly less behavioural pain expression. Conclusions: Glucose is associated with no significant cortical activation and may interfere with pain-associated response at the cortical level. Conversely, breastfeeding analgesia is associated with generalized cortical activation and may act by multisensory stimulation, possibly overwhelming pain perception.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalNeonatology
Volume104
Issue number4
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Functional Neuroimaging
Near-Infrared Spectroscopy
Breast Feeding
Analgesia
Pain
Glucose
Analgesics
Pain Perception
Somatosensory Cortex
Heel
Hemoglobins

Keywords

  • Cortical activation
  • Multisensory experience
  • Near-infrared spectroscopy
  • Pain in newborns

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Functional neuroimaging of breastfeeding analgesia by multichannel near-infrared spectroscopy. / Bembich, Stefano; Davanzo, Riccardo; Brovedani, Pierpaolo; Clarici, Andrea; Massaccesi, Stefano; Demarini, Sergio.

In: Neonatology, Vol. 104, No. 4, 11.2013, p. 255-259.

Research output: Contribution to journalArticle

Bembich, S, Davanzo, R, Brovedani, P, Clarici, A, Massaccesi, S & Demarini, S 2013, 'Functional neuroimaging of breastfeeding analgesia by multichannel near-infrared spectroscopy', Neonatology, vol. 104, no. 4, pp. 255-259. https://doi.org/10.1159/000353386
Bembich, Stefano ; Davanzo, Riccardo ; Brovedani, Pierpaolo ; Clarici, Andrea ; Massaccesi, Stefano ; Demarini, Sergio. / Functional neuroimaging of breastfeeding analgesia by multichannel near-infrared spectroscopy. In: Neonatology. 2013 ; Vol. 104, No. 4. pp. 255-259.
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