Functional neuroimaging (PET and SPECT) in the selection and assessment of patients with Parkinson's disease undergoing deep brain stimulation

A. Antonini, A. Landi, R. Benti, C. Mariani, R. De Notaris, G. Marotta, G. Pezzoli, S. M. Gaini, P. Gerundini

Research output: Contribution to journalArticle

Abstract

Deep brain Stimulation (DBS) is an effective treatment for patients with advanced Parkinson's disease (PD) and motor complications who can no longer be improved by adjustment of medical therapy. Selection of surgery candidates and follow-up after surgery are critical for good outcome. Functional neuroimaging can help in the clinical assessment of these patients. We have used single photon emission computed tomography (SPECT) and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the subthalamic nucleus (STN) in 20 patients with advanced PD. We found a significant increase in the anterior cingulate/supplementary motor cortex in the 12 good responders (change in off unified UPDRS >50%). Conversely, patients with poor response (n=8; change in off UPDRS-III

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalJournal of Neurosurgical Sciences
Volume47
Issue number1
Publication statusPublished - Mar 2003

Keywords

  • Brain
  • Parkinson disease, radionuclide imaging
  • Tomography, emission computed
  • Tomography, emission computed, single photon

ASJC Scopus subject areas

  • Clinical Neurology

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