Abstract
Deep brain Stimulation (DBS) is an effective treatment for patients with advanced Parkinson's disease (PD) and motor complications who can no longer be improved by adjustment of medical therapy. Selection of surgery candidates and follow-up after surgery are critical for good outcome. Functional neuroimaging can help in the clinical assessment of these patients. We have used single photon emission computed tomography (SPECT) and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the subthalamic nucleus (STN) in 20 patients with advanced PD. We found a significant increase in the anterior cingulate/supplementary motor cortex in the 12 good responders (change in off unified UPDRS >50%). Conversely, patients with poor response (n=8; change in off UPDRS-III
| Original language | English |
|---|---|
| Pages (from-to) | 40-46 |
| Number of pages | 7 |
| Journal | Journal of Neurosurgical Sciences |
| Volume | 47 |
| Issue number | 1 |
| Publication status | Published - Mar 2003 |
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Keywords
- Brain
- Parkinson disease, radionuclide imaging
- Tomography, emission computed
- Tomography, emission computed, single photon
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Functional neuroimaging (PET and SPECT) in the selection and assessment of patients with Parkinson's disease undergoing deep brain stimulation. / Antonini, A.; Landi, A.; Benti, R.; Mariani, C.; De Notaris, R.; Marotta, G.; Pezzoli, G.; Gaini, S. M.; Gerundini, P.
In: Journal of Neurosurgical Sciences, Vol. 47, No. 1, 03.2003, p. 40-46.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional neuroimaging (PET and SPECT) in the selection and assessment of patients with Parkinson's disease undergoing deep brain stimulation
AU - Antonini, A.
AU - Landi, A.
AU - Benti, R.
AU - Mariani, C.
AU - De Notaris, R.
AU - Marotta, G.
AU - Pezzoli, G.
AU - Gaini, S. M.
AU - Gerundini, P.
PY - 2003/3
Y1 - 2003/3
N2 - Deep brain Stimulation (DBS) is an effective treatment for patients with advanced Parkinson's disease (PD) and motor complications who can no longer be improved by adjustment of medical therapy. Selection of surgery candidates and follow-up after surgery are critical for good outcome. Functional neuroimaging can help in the clinical assessment of these patients. We have used single photon emission computed tomography (SPECT) and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the subthalamic nucleus (STN) in 20 patients with advanced PD. We found a significant increase in the anterior cingulate/supplementary motor cortex in the 12 good responders (change in off unified UPDRS >50%). Conversely, patients with poor response (n=8; change in off UPDRS-III
AB - Deep brain Stimulation (DBS) is an effective treatment for patients with advanced Parkinson's disease (PD) and motor complications who can no longer be improved by adjustment of medical therapy. Selection of surgery candidates and follow-up after surgery are critical for good outcome. Functional neuroimaging can help in the clinical assessment of these patients. We have used single photon emission computed tomography (SPECT) and the tracer ECD to measure regional cerebral blood flow before and 6 months after DBS of the subthalamic nucleus (STN) in 20 patients with advanced PD. We found a significant increase in the anterior cingulate/supplementary motor cortex in the 12 good responders (change in off unified UPDRS >50%). Conversely, patients with poor response (n=8; change in off UPDRS-III
KW - Brain
KW - Parkinson disease, radionuclide imaging
KW - Tomography, emission computed
KW - Tomography, emission computed, single photon
UR - http://www.scopus.com/inward/record.url?scp=0042737409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042737409&partnerID=8YFLogxK
M3 - Article
VL - 47
SP - 40
EP - 46
JO - Journal of Neurosurgical Sciences
JF - Journal of Neurosurgical Sciences
SN - 0026-4881
IS - 1
ER -