Functional opioid activity variates according to the different fashion of alcohol abuse

F. Facchinetti, F. Petraglia, G. Nappi, E. Martignoni, E. Sinforiani, G. Bono, A. R. Genazzani

Research output: Contribution to journalArticle

Abstract

Two groups of alcohol addicts (total of 14 subjects), were submitted to Traditional Manual Acupuncture and pituitary hormone plasma levels, including B-Endorphin (B-EP), were measured in basal condition and after 1, 5, 20 and 60 minutes from needle withdrawal. Group A patients had a polarity towards negative affective tone presenting signs of dysphoria while group B was composed of the so-called 'social drinkers'. No difference existed in basal hormonal values, except slightly elevated plasma B-EP levels in group A. No significant responses to TMA were recorded in plasma ACTH, Cortisol, Prolactin or GH levels in groups A and B. Social drinkers showed an increase of B-EP plasma levelsin response to TMA (128 ± 62.1%, ̄ ± SD) which on the contrary was absent in dysphoric alcoholics (2.8 ± 38.6%, p

Original languageEnglish
Pages (from-to)281-291
Number of pages11
JournalSubstance and Alcohol Actions/Misuse
Volume5
Issue number6
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Medicine(all)

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    Facchinetti, F., Petraglia, F., Nappi, G., Martignoni, E., Sinforiani, E., Bono, G., & Genazzani, A. R. (1984). Functional opioid activity variates according to the different fashion of alcohol abuse. Substance and Alcohol Actions/Misuse, 5(6), 281-291.