Functional outcome after lower limb amputation: Is hyperhomocysteinemia a predictive factor?: An Observational Study

Stefano Brunelli, Augusto Fusco, Marco Iosa, Elena Ricciardi, Marco Traballesi

Research output: Contribution to journalArticle

Abstract

Lower limb amputation (LLA) is the drastic stage of peripheral arterial disease (PAD) where the hyperhomocysteinemia (H-HCY) seems to be a risk factor. Surprisingly, in literature the levels and the role of homocysteinemia (HCY) in persons with LLA are understudied. This study aims to investigate the level of HCY and its correlation with the functional outcomes after LLA. A case-control study to analyze HCY levels in amputees admitted in a rehabilitation hospital during an investigation period of 1.5 years. Barthel Index was used to assess the functional outcome. We enrolled 91 dysvascular amputees and 44 amputees for other reasons than PAD (controls). The mean level of HCY was found higher in dysvascular amputees (15.2±7.5) compared to controls (11.0±5.0, P

Original languageEnglish
Article numbere2167
JournalMedicine (United States)
Volume94
Issue number49
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Medicine(all)

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