Functional outcomes of nerve-sparing laparoscopic eradication of deep infiltrating endometriosis: a prospective analysis using validated questionnaires

Stefano Uccella, Baldo Gisone, Maurizio Serati, Sara Biasoli, Nicola Marconi, Gloria Angeretti, Valerio Gallotta, Silvia Cardinale, Stefano Rausei, Gianlorenzo Dionigi, Giovanni Scambia, Fabio Ghezzi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Radical eradication of deep infiltrating endometriosis (DIE) is associated with a high risk of iatrogenic autonomic denervation and pelvic dysfunction. Our aim was to prospectively analyze peri-operative details and post-operative functional outcomes (in terms of pain relief and bladder, rectal, and sexual function) among women operated for DIE of the posterior compartment with nerve-sparing technique, using the visual analogue scale and validated questionnaires. Methods: All women undergoing laparoscopic nerve-sparing eradicative surgery for DIE nodules of the posterior compartment ≥ 4 cm ± bowel resection were included. Pain scores [using Visual Analogue Scale (VAS) scores] were collected before surgery and 6 and 12 months after surgery. Functional outcomes in terms of bladder, rectal, and sexual function, were evaluated using validated questionnaires (i.e., ICIQ-UISF, NBD score, and FSFI) administered pre-operatively and 6 months after surgery. Main results: A total of 34 patients were included. Twenty-eight (82.4%) of them had already undergone a previous abdominal surgery for endometriosis. Bowel resection was performed in 16 (47.1%) patients. Median VAS score levels of pelvic pain were significantly decreased after surgery both at 6 (median 3, range 0–7 and 2, 0–7, respectively) and at 12 months (3, 0–8 and 2, 0–7), compared to pre-operative levels (9, 1–10 and 3, 0–7, respectively) (p < 0.0001). No differences were found in terms of urinary function between pre- and post-operative ICIQ-SF questionnaires. In no cases, bladder self-catheterization was needed at the 6-and 12-month follow-up. Median NBD score was 3.5 (0–21) pre-operatively and 2 (0–18) after 6 months (p = 0.72). The pre-operative total FSFI score was 19.1 (1.2–28.9) vs. 22.7 (12.2–31) post-operatively (p = 0.004). Conclusions: The nerve-sparing approach is effective in eradicating DIE of the posterior compartment, with satisfactory pain control, significant improvement of sexual function, and preservation of bladder and rectal function.

Original languageEnglish
Pages (from-to)639-647
Number of pages9
JournalArchives of Gynecology and Obstetrics
Volume298
Issue number3
DOIs
Publication statusPublished - Sep 1 2018

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Endometriosis
Urinary Bladder
Visual Analog Scale
Pain
Autonomic Denervation
Pelvic Pain
Catheterization
Surveys and Questionnaires

Keywords

  • Bladder function
  • Deep infiltrating endometriosis
  • Laparoscopy
  • Nerve sparing
  • Rectal function
  • Sexual function

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Functional outcomes of nerve-sparing laparoscopic eradication of deep infiltrating endometriosis : a prospective analysis using validated questionnaires. / Uccella, Stefano; Gisone, Baldo; Serati, Maurizio; Biasoli, Sara; Marconi, Nicola; Angeretti, Gloria; Gallotta, Valerio; Cardinale, Silvia; Rausei, Stefano; Dionigi, Gianlorenzo; Scambia, Giovanni; Ghezzi, Fabio.

In: Archives of Gynecology and Obstetrics, Vol. 298, No. 3, 01.09.2018, p. 639-647.

Research output: Contribution to journalArticle

Uccella, Stefano ; Gisone, Baldo ; Serati, Maurizio ; Biasoli, Sara ; Marconi, Nicola ; Angeretti, Gloria ; Gallotta, Valerio ; Cardinale, Silvia ; Rausei, Stefano ; Dionigi, Gianlorenzo ; Scambia, Giovanni ; Ghezzi, Fabio. / Functional outcomes of nerve-sparing laparoscopic eradication of deep infiltrating endometriosis : a prospective analysis using validated questionnaires. In: Archives of Gynecology and Obstetrics. 2018 ; Vol. 298, No. 3. pp. 639-647.
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abstract = "Purpose: Radical eradication of deep infiltrating endometriosis (DIE) is associated with a high risk of iatrogenic autonomic denervation and pelvic dysfunction. Our aim was to prospectively analyze peri-operative details and post-operative functional outcomes (in terms of pain relief and bladder, rectal, and sexual function) among women operated for DIE of the posterior compartment with nerve-sparing technique, using the visual analogue scale and validated questionnaires. Methods: All women undergoing laparoscopic nerve-sparing eradicative surgery for DIE nodules of the posterior compartment ≥ 4 cm ± bowel resection were included. Pain scores [using Visual Analogue Scale (VAS) scores] were collected before surgery and 6 and 12 months after surgery. Functional outcomes in terms of bladder, rectal, and sexual function, were evaluated using validated questionnaires (i.e., ICIQ-UISF, NBD score, and FSFI) administered pre-operatively and 6 months after surgery. Main results: A total of 34 patients were included. Twenty-eight (82.4{\%}) of them had already undergone a previous abdominal surgery for endometriosis. Bowel resection was performed in 16 (47.1{\%}) patients. Median VAS score levels of pelvic pain were significantly decreased after surgery both at 6 (median 3, range 0–7 and 2, 0–7, respectively) and at 12 months (3, 0–8 and 2, 0–7), compared to pre-operative levels (9, 1–10 and 3, 0–7, respectively) (p < 0.0001). No differences were found in terms of urinary function between pre- and post-operative ICIQ-SF questionnaires. In no cases, bladder self-catheterization was needed at the 6-and 12-month follow-up. Median NBD score was 3.5 (0–21) pre-operatively and 2 (0–18) after 6 months (p = 0.72). The pre-operative total FSFI score was 19.1 (1.2–28.9) vs. 22.7 (12.2–31) post-operatively (p = 0.004). Conclusions: The nerve-sparing approach is effective in eradicating DIE of the posterior compartment, with satisfactory pain control, significant improvement of sexual function, and preservation of bladder and rectal function.",
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T1 - Functional outcomes of nerve-sparing laparoscopic eradication of deep infiltrating endometriosis

T2 - a prospective analysis using validated questionnaires

AU - Uccella, Stefano

AU - Gisone, Baldo

AU - Serati, Maurizio

AU - Biasoli, Sara

AU - Marconi, Nicola

AU - Angeretti, Gloria

AU - Gallotta, Valerio

AU - Cardinale, Silvia

AU - Rausei, Stefano

AU - Dionigi, Gianlorenzo

AU - Scambia, Giovanni

AU - Ghezzi, Fabio

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Purpose: Radical eradication of deep infiltrating endometriosis (DIE) is associated with a high risk of iatrogenic autonomic denervation and pelvic dysfunction. Our aim was to prospectively analyze peri-operative details and post-operative functional outcomes (in terms of pain relief and bladder, rectal, and sexual function) among women operated for DIE of the posterior compartment with nerve-sparing technique, using the visual analogue scale and validated questionnaires. Methods: All women undergoing laparoscopic nerve-sparing eradicative surgery for DIE nodules of the posterior compartment ≥ 4 cm ± bowel resection were included. Pain scores [using Visual Analogue Scale (VAS) scores] were collected before surgery and 6 and 12 months after surgery. Functional outcomes in terms of bladder, rectal, and sexual function, were evaluated using validated questionnaires (i.e., ICIQ-UISF, NBD score, and FSFI) administered pre-operatively and 6 months after surgery. Main results: A total of 34 patients were included. Twenty-eight (82.4%) of them had already undergone a previous abdominal surgery for endometriosis. Bowel resection was performed in 16 (47.1%) patients. Median VAS score levels of pelvic pain were significantly decreased after surgery both at 6 (median 3, range 0–7 and 2, 0–7, respectively) and at 12 months (3, 0–8 and 2, 0–7), compared to pre-operative levels (9, 1–10 and 3, 0–7, respectively) (p < 0.0001). No differences were found in terms of urinary function between pre- and post-operative ICIQ-SF questionnaires. In no cases, bladder self-catheterization was needed at the 6-and 12-month follow-up. Median NBD score was 3.5 (0–21) pre-operatively and 2 (0–18) after 6 months (p = 0.72). The pre-operative total FSFI score was 19.1 (1.2–28.9) vs. 22.7 (12.2–31) post-operatively (p = 0.004). Conclusions: The nerve-sparing approach is effective in eradicating DIE of the posterior compartment, with satisfactory pain control, significant improvement of sexual function, and preservation of bladder and rectal function.

AB - Purpose: Radical eradication of deep infiltrating endometriosis (DIE) is associated with a high risk of iatrogenic autonomic denervation and pelvic dysfunction. Our aim was to prospectively analyze peri-operative details and post-operative functional outcomes (in terms of pain relief and bladder, rectal, and sexual function) among women operated for DIE of the posterior compartment with nerve-sparing technique, using the visual analogue scale and validated questionnaires. Methods: All women undergoing laparoscopic nerve-sparing eradicative surgery for DIE nodules of the posterior compartment ≥ 4 cm ± bowel resection were included. Pain scores [using Visual Analogue Scale (VAS) scores] were collected before surgery and 6 and 12 months after surgery. Functional outcomes in terms of bladder, rectal, and sexual function, were evaluated using validated questionnaires (i.e., ICIQ-UISF, NBD score, and FSFI) administered pre-operatively and 6 months after surgery. Main results: A total of 34 patients were included. Twenty-eight (82.4%) of them had already undergone a previous abdominal surgery for endometriosis. Bowel resection was performed in 16 (47.1%) patients. Median VAS score levels of pelvic pain were significantly decreased after surgery both at 6 (median 3, range 0–7 and 2, 0–7, respectively) and at 12 months (3, 0–8 and 2, 0–7), compared to pre-operative levels (9, 1–10 and 3, 0–7, respectively) (p < 0.0001). No differences were found in terms of urinary function between pre- and post-operative ICIQ-SF questionnaires. In no cases, bladder self-catheterization was needed at the 6-and 12-month follow-up. Median NBD score was 3.5 (0–21) pre-operatively and 2 (0–18) after 6 months (p = 0.72). The pre-operative total FSFI score was 19.1 (1.2–28.9) vs. 22.7 (12.2–31) post-operatively (p = 0.004). Conclusions: The nerve-sparing approach is effective in eradicating DIE of the posterior compartment, with satisfactory pain control, significant improvement of sexual function, and preservation of bladder and rectal function.

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KW - Deep infiltrating endometriosis

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KW - Nerve sparing

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