Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder

J. Deckert; M. Catalano; A. Heils; D. Di Bella; F. Friess; E. Politi; P. Franke; M. M. Nöthen; W. Maier; L. Bellodi; K. P. Lesch

Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder

J. Deckert, M. Catalano, A. Heils, D. Di Bella, F. Friess, E. Politi, P. Franke, M. M. Nöthen, W. Maier, L. Bellodi, K. P. Lesch

Research output: Contribution to journal › Article › peer-review

Abstract

To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (χ² analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.

Original language	English
Pages (from-to)	45-47
Number of pages	3
Journal	Psychiatric Genetics
Volume	7
Issue number	1
Publication status	Published - 1997

Keywords

Panic disorder
Promoter variant
Serotonin transporter

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Genetics
Neuroscience(all)

Cite this

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T2 - Lack of association with panic disorder

AU - Deckert, J.

AU - Catalano, M.

AU - Heils, A.

AU - Di Bella, D.

AU - Friess, F.

AU - Politi, E.

AU - Franke, P.

AU - Nöthen, M. M.

AU - Maier, W.

AU - Bellodi, L.

AU - Lesch, K. P.

PY - 1997

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AB - To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (χ2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.

KW - Panic disorder

KW - Promoter variant

KW - Serotonin transporter

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Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder

Abstract

Keywords

ASJC Scopus subject areas

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