Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder

J. Deckert, M. Catalano, A. Heils, D. Di Bella, F. Friess, E. Politi, P. Franke, M. M. Nöthen, W. Maier, L. Bellodi, K. P. Lesch

Research output: Contribution to journal › Article

106 Citations (Scopus)

Abstract

To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (χ2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalPsychiatric Genetics
Volume7
Issue number1
Publication statusPublished - 1997

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Panic Disorder
Gene Frequency

Keywords

  • Panic disorder
  • Promoter variant
  • Serotonin transporter

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Deckert, J., Catalano, M., Heils, A., Di Bella, D., Friess, F., Politi, E., ... Lesch, K. P. (1997). Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder. Psychiatric Genetics, 7(1), 45-47.

Functional promoter polymorphism of the human serotonin transporter : Lack of association with panic disorder. / Deckert, J.; Catalano, M.; Heils, A.; Di Bella, D.; Friess, F.; Politi, E.; Franke, P.; Nöthen, M. M.; Maier, W.; Bellodi, L.; Lesch, K. P.

In: Psychiatric Genetics, Vol. 7, No. 1, 1997, p. 45-47.

Research output: Contribution to journal › Article

Deckert, J, Catalano, M, Heils, A, Di Bella, D, Friess, F, Politi, E, Franke, P, Nöthen, MM, Maier, W, Bellodi, L & Lesch, KP 1997, 'Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder', Psychiatric Genetics, vol. 7, no. 1, pp. 45-47.
Deckert J, Catalano M, Heils A, Di Bella D, Friess F, Politi E et al. Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder. Psychiatric Genetics. 1997;7(1):45-47.
Deckert, J. ; Catalano, M. ; Heils, A. ; Di Bella, D. ; Friess, F. ; Politi, E. ; Franke, P. ; Nöthen, M. M. ; Maier, W. ; Bellodi, L. ; Lesch, K. P. / Functional promoter polymorphism of the human serotonin transporter : Lack of association with panic disorder. In: Psychiatric Genetics. 1997 ; Vol. 7, No. 1. pp. 45-47.
@article{f1fd8de8cb1443a487e7e99f84c0972c,
title = "Functional promoter polymorphism of the human serotonin transporter: Lack of association with panic disorder",
abstract = "To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (χ2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.",
keywords = "Panic disorder, Promoter variant, Serotonin transporter",
author = "J. Deckert and M. Catalano and A. Heils and {Di Bella}, D. and F. Friess and E. Politi and P. Franke and N{\"o}then, {M. M.} and W. Maier and L. Bellodi and Lesch, {K. P.}",
year = "1997",
language = "English",
volume = "7",
pages = "45--47",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Functional promoter polymorphism of the human serotonin transporter

T2 - Lack of association with panic disorder

AU - Deckert, J.

AU - Catalano, M.

AU - Heils, A.

AU - Di Bella, D.

AU - Friess, F.

AU - Politi, E.

AU - Franke, P.

AU - Nöthen, M. M.

AU - Maier, W.

AU - Bellodi, L.

AU - Lesch, K. P.

PY - 1997

Y1 - 1997

N2 - To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (χ2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.

AB - To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (χ2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.

KW - Panic disorder

KW - Promoter variant

KW - Serotonin transporter

UR - http://www.scopus.com/inward/record.url?scp=8544260300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8544260300&partnerID=8YFLogxK

M3 - Article

C2 - 9264139

AN - SCOPUS:8544260300

VL - 7

SP - 45

EP - 47

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 1

ER -

Access to Document