Functional recovery in subcortical crossed and standard aphasia

Pasquale A. Della Rosa, Matteo Canini, Virginia M. Borsa, Peter Mariën, Stefano F. Cappa, Jubin Abutalebi

Research output: Contribution to journalArticlepeer-review


There are very few longitudinal studies investigating functional recovery in aphasics affected by subcortical lesions. In addition, no longitudinal follow-up studies exist of patients with subcortical crossed aphasia.Our aim was to investigate functional recovery in two anomic patients with subcortical aphasia, one crossed aphasia and one standard, uncrossed aphasia due to a similar subcortical lesion. An er-fMRI follow-up paradigm was employed during a picture-naming task. Both patients were scanned prior to speech therapy (T0), after 3 months of anomia-specific rehabilitation (T1) and following 6 months of conventional language rehabilitation (T2). Irrespectively of lesion lateralization, fMRI data disclosed a grounding role for homologue naming-specific areas (respectively, LIFG and RIFG) in determining the progressive pattern of behavioural naming recovery throughout different disease phases. Thus, functional recovery, parallelled by improvement in behavioural naming performance, seems to be strictly related to recruitment of homologue areas in the hemisphere opposite to the aphasiogenic lesion.

Original languageEnglish
Pages (from-to)103-118
Number of pages16
JournalJournal of Neurolinguistics
Issue number1
Publication statusPublished - Jan 2014


  • Aphasia recovery
  • Crossed aphasia
  • Functional neuroimaging
  • Functional recovery
  • Subcortical aphasia

ASJC Scopus subject areas

  • Linguistics and Language
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)


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