Abstract
An intravenous infusion of 2,000 ml isotonic saline was performed in 8 normotensive, normoreninemic patients with progressive systemic sclerosis. None of them had clinical evidence of renal disease. Total and proximal fractional excretion compared with that of 8 normal subjects. No correlation was found with para-aminohippurate (PAH) clearance values. Two years after this study was done, 4 patients developed arterial hypertension; interestingly, plasma-renin activity remained within the normal range. Reduced sodium excretion is suggested as having a pathogenetic role in the hypertension of progressive systemic sclerosis.
Translated title of the contribution | Functional renal involvement in normotensive patients with progressive systemic sclerosis (Impaired sodium excretion during isotonic saline infusion) |
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Original language | Portuguese |
Pages (from-to) | 225-232 |
Number of pages | 8 |
Journal | Arquivos de Reumatologia e Doencas Osteo-Articulares |
Volume | 3 |
Issue number | 6 |
Publication status | Published - 1982 |
ASJC Scopus subject areas
- Rheumatology