An intravenous infusion of 2,000 ml isotonic saline was performed in 8 normotensive, normoreninemic patients with progressive systemic sclerosis. None of them had clinical evidence of renal disease. Total and proximal fractional excretion compared with that of 8 normal subjects. No correlation was found with para-aminohippurate (PAH) clearance values. Two years after this study was done, 4 patients developed arterial hypertension; interestingly, plasma-renin activity remained within the normal range. Reduced sodium excretion is suggested as having a pathogenetic role in the hypertension of progressive systemic sclerosis.
|Translated title of the contribution||Functional renal involvement in normotensive patients with progressive systemic sclerosis (Impaired sodium excretion during isotonic saline infusion)|
|Number of pages||8|
|Journal||Arquivos de Reumatologia e Doencas Osteo-Articulares|
|Publication status||Published - 1982|
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