Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact?

Pamela Fischer-Posovszky, Julian Roos, Primoz Kotnik, Tadej Battelino, Elena Inzaghi, Valerio Nobili, Stefano Cianfarani, Martin Wabitsch

Research output: Contribution to journalReview article

Abstract

Obesity is a major health concern. While some children develop comorbidities such as insulin resistance and low-grade systemic inflammation upon weight gain, others stay metabolically healthy. There is an urgent need for clinically relevant markers with prognostic value related to disease development and intervention success. MicroRNAs (miRNAs) are established biomarkers for several disease states. Herein, we give a brief overview of miRNA biogenesis and function and the potential role of circulating miRNA in the context of pediatric obesity.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalHormone Research in Paediatrics
Volume86
Issue number1
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Biogenesis
  • Childhood obesity
  • MicroRNA

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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