Functional topography of the fully grown human oocyte

Manuela Monti, Alberto Calligaro, Barry Behr, Renee Rejo Pera, Carlo Alberto Redi, Mark Wossidlo

Research output: Contribution to journalArticlepeer-review


In vivo maturation (IVM) of human oocytes is a technique used to increase the number of usable oocytes for in vitro fertilization (IVF) and represents a necessity for women with different ovarian pathologies. During IVM the oocytes progress from the germinal vesicle stage (GV) through the metaphase II and during this journey both nuclear and cytoplasmic rearrangements must be obtained to increase the probability to get viable and healthy zygotes/embryos after IVF. As the successful clinical outcomes of this technique are a reality, we wanted to investigate the causes behind oocytes maturation arrest. For obvious ethical reasons, we were able to analyze only few human immature oocytes discarded and donated to research by transmission electron microscopy showing that, as in the mouse, they have different chromatin and cytoplasmic organizations both essential for further embryo development.

Original languageEnglish
Article number2769
Pages (from-to)32-35
Number of pages4
JournalEuropean Journal of Histochemistry
Issue number1
Publication statusPublished - Feb 6 2017


  • Cytoplasmic lattices
  • Human antral compartment
  • Human oocytes
  • Lipid droplets
  • NSN oocytes
  • SN oocytes
  • Transmission electron microscopy

ASJC Scopus subject areas

  • Biophysics
  • Histology
  • Cell Biology


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