Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli

An fMRI study

Antonio Ferretti, Claudio Babiloni, Cosimo Del Gratta, Massimo Caulo, Armando Tartaro, Lorenzo Bonomo, Paolo Maria Rossini, Gian Luca Romani

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The regional activity of the contralateral primary (SI) and the bilateral secondary (SII) somatosensory areas during median nerve stimulations at five intensity levels (ranging from nonpainful motor threshold to moderate pain) was studied by means of functional magnetic resonance imaging (fMRI). The aim was to characterize the functional topography of SII compared to SI as a function of the stimulus intensity. Results showed that the galvanic stimulation of the median nerve activated the contralateral SI at all stimulus intensities. When considered as a single region, SII was more strongly activated in the contralateral than in the ipsilateral hemisphere. When a finer spatial analysis of the SII responses was performed, the activity for the painful stimulation was localized more posteriorly compared to that for the nonpainful stimulation. This is the first report on such a SII segregation for transient galvanic stimulations. The activity (relative signal intensity) of this posterior area increased with the increase of the stimulus intensity. These results suggest a spatial segregation of the neural populations that process signals conveyed by dorsal column-medial lemniscus (nonpainful signals) and neospinothalamic (painful signals) pathways. Further fMRI experiments should evaluate the functional properties of these two SII subregions during tasks involving sensorimotor integration, learning, and memory demands.

Original languageEnglish
Pages (from-to)1625-1638
Number of pages14
JournalNeuroImage
Volume20
Issue number3
DOIs
Publication statusPublished - Nov 2003

Fingerprint

Somatosensory Cortex
Median Nerve
Magnetic Resonance Imaging
Spatial Analysis
Signal Transduction
Learning
Pain
Population

Keywords

  • Functional magnetic resonance imaging (fMRI)
  • Median-nerve electrical stimulation
  • Pain
  • Primary somatosensory area (SI)
  • Secondary somatosensory area (SII)

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Ferretti, A., Babiloni, C., Del Gratta, C., Caulo, M., Tartaro, A., Bonomo, L., ... Romani, G. L. (2003). Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli: An fMRI study. NeuroImage, 20(3), 1625-1638. https://doi.org/10.1016/j.neuroimage.2003.07.004

Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli : An fMRI study. / Ferretti, Antonio; Babiloni, Claudio; Del Gratta, Cosimo; Caulo, Massimo; Tartaro, Armando; Bonomo, Lorenzo; Rossini, Paolo Maria; Romani, Gian Luca.

In: NeuroImage, Vol. 20, No. 3, 11.2003, p. 1625-1638.

Research output: Contribution to journalArticle

Ferretti, A, Babiloni, C, Del Gratta, C, Caulo, M, Tartaro, A, Bonomo, L, Rossini, PM & Romani, GL 2003, 'Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli: An fMRI study', NeuroImage, vol. 20, no. 3, pp. 1625-1638. https://doi.org/10.1016/j.neuroimage.2003.07.004
Ferretti, Antonio ; Babiloni, Claudio ; Del Gratta, Cosimo ; Caulo, Massimo ; Tartaro, Armando ; Bonomo, Lorenzo ; Rossini, Paolo Maria ; Romani, Gian Luca. / Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli : An fMRI study. In: NeuroImage. 2003 ; Vol. 20, No. 3. pp. 1625-1638.
@article{4860ebcb459c4dbdba67de51770be0ea,
title = "Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli: An fMRI study",
abstract = "The regional activity of the contralateral primary (SI) and the bilateral secondary (SII) somatosensory areas during median nerve stimulations at five intensity levels (ranging from nonpainful motor threshold to moderate pain) was studied by means of functional magnetic resonance imaging (fMRI). The aim was to characterize the functional topography of SII compared to SI as a function of the stimulus intensity. Results showed that the galvanic stimulation of the median nerve activated the contralateral SI at all stimulus intensities. When considered as a single region, SII was more strongly activated in the contralateral than in the ipsilateral hemisphere. When a finer spatial analysis of the SII responses was performed, the activity for the painful stimulation was localized more posteriorly compared to that for the nonpainful stimulation. This is the first report on such a SII segregation for transient galvanic stimulations. The activity (relative signal intensity) of this posterior area increased with the increase of the stimulus intensity. These results suggest a spatial segregation of the neural populations that process signals conveyed by dorsal column-medial lemniscus (nonpainful signals) and neospinothalamic (painful signals) pathways. Further fMRI experiments should evaluate the functional properties of these two SII subregions during tasks involving sensorimotor integration, learning, and memory demands.",
keywords = "Functional magnetic resonance imaging (fMRI), Median-nerve electrical stimulation, Pain, Primary somatosensory area (SI), Secondary somatosensory area (SII)",
author = "Antonio Ferretti and Claudio Babiloni and {Del Gratta}, Cosimo and Massimo Caulo and Armando Tartaro and Lorenzo Bonomo and Rossini, {Paolo Maria} and Romani, {Gian Luca}",
year = "2003",
month = "11",
doi = "10.1016/j.neuroimage.2003.07.004",
language = "English",
volume = "20",
pages = "1625--1638",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli

T2 - An fMRI study

AU - Ferretti, Antonio

AU - Babiloni, Claudio

AU - Del Gratta, Cosimo

AU - Caulo, Massimo

AU - Tartaro, Armando

AU - Bonomo, Lorenzo

AU - Rossini, Paolo Maria

AU - Romani, Gian Luca

PY - 2003/11

Y1 - 2003/11

N2 - The regional activity of the contralateral primary (SI) and the bilateral secondary (SII) somatosensory areas during median nerve stimulations at five intensity levels (ranging from nonpainful motor threshold to moderate pain) was studied by means of functional magnetic resonance imaging (fMRI). The aim was to characterize the functional topography of SII compared to SI as a function of the stimulus intensity. Results showed that the galvanic stimulation of the median nerve activated the contralateral SI at all stimulus intensities. When considered as a single region, SII was more strongly activated in the contralateral than in the ipsilateral hemisphere. When a finer spatial analysis of the SII responses was performed, the activity for the painful stimulation was localized more posteriorly compared to that for the nonpainful stimulation. This is the first report on such a SII segregation for transient galvanic stimulations. The activity (relative signal intensity) of this posterior area increased with the increase of the stimulus intensity. These results suggest a spatial segregation of the neural populations that process signals conveyed by dorsal column-medial lemniscus (nonpainful signals) and neospinothalamic (painful signals) pathways. Further fMRI experiments should evaluate the functional properties of these two SII subregions during tasks involving sensorimotor integration, learning, and memory demands.

AB - The regional activity of the contralateral primary (SI) and the bilateral secondary (SII) somatosensory areas during median nerve stimulations at five intensity levels (ranging from nonpainful motor threshold to moderate pain) was studied by means of functional magnetic resonance imaging (fMRI). The aim was to characterize the functional topography of SII compared to SI as a function of the stimulus intensity. Results showed that the galvanic stimulation of the median nerve activated the contralateral SI at all stimulus intensities. When considered as a single region, SII was more strongly activated in the contralateral than in the ipsilateral hemisphere. When a finer spatial analysis of the SII responses was performed, the activity for the painful stimulation was localized more posteriorly compared to that for the nonpainful stimulation. This is the first report on such a SII segregation for transient galvanic stimulations. The activity (relative signal intensity) of this posterior area increased with the increase of the stimulus intensity. These results suggest a spatial segregation of the neural populations that process signals conveyed by dorsal column-medial lemniscus (nonpainful signals) and neospinothalamic (painful signals) pathways. Further fMRI experiments should evaluate the functional properties of these two SII subregions during tasks involving sensorimotor integration, learning, and memory demands.

KW - Functional magnetic resonance imaging (fMRI)

KW - Median-nerve electrical stimulation

KW - Pain

KW - Primary somatosensory area (SI)

KW - Secondary somatosensory area (SII)

UR - http://www.scopus.com/inward/record.url?scp=0344121167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344121167&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2003.07.004

DO - 10.1016/j.neuroimage.2003.07.004

M3 - Article

VL - 20

SP - 1625

EP - 1638

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3

ER -