Functionalization of biomimetic calcium phosphate bone cements with alendronate

S. Panzavolta, P. Torricelli, B. Bracci, M. Fini, A. Bigi

Research output: Contribution to journalArticle

Abstract

Bisphosphonates (BPs) are widely employed for the treatment of a variety of bone disorders. We have previously successfully added small amounts of BPs into calcium phosphate bone cements in order to enhance their bio-functionality. In this work we were able to increase greatly the amount of BP introduced in the cement, thanks to suitable modifications of composition. In particular, we utilized biomimetic α-tricalcium phosphate (α-TCP) cements at different gelatin contents (10, 15 and 20. wt.%) to introduce Disodium Alendronate up to a concentration of 25. mM. Due to the small liquid/powder ratio (0.22. ml/g) the lengthening of the setting times due to alendronate is quite modest. The rate of transformation of α-TCP into calcium deficient hydroxyapatite slightly decreases as a function of alendronate content, whereas it increases with increasing gelatin concentration. Moreover, relatively high alendronate concentrations provoke significant reduction of the compressive strength of the cements. The results of in vitro tests indicate that alendronate-containing cements significantly affect osteoclast proliferation and differentiation, whereas they promote osteoblast differentiation, to an extent which depends on cement composition.

Original languageEnglish
Pages (from-to)1099-1106
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume104
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Bisphosphonate
  • Bone cement
  • Calcium phosphates
  • Gelatin

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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