Functionalized gold nanoparticles: A detailed in vivo multimodal microscopic brain distribution study

Fernanda Sousa, Subhra Mandal, Chiara Garrovo, Alberto Astolfo, Alois Bonifacio, Diane Latawiec, Ralf Hendrik Menk, Fulvia Arfelli, Sabine Huewel, Giuseppe Legname, Hans Joachim Galla, Silke Krol

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Abstract

In the present study, the in vivo distribution of polyelectrolyte multilayer coated gold nanoparticles is shown, starting from the living animal down to cellular level. The coating was designed with functional moieties to serve as a potential nano drug for prion disease. With near infrared time-domain imaging we followed the biodistribution in mice up to 7 days after intravenous injection of the nanoparticles. The peak concentration in the head of mice was detected between 19 and 24 h. The precise particle distribution in the brain was studied ex vivo by X-ray microtomography, confocal laser and fluorescence microscopy. We found that the particles mainly accumulate in the hippocampus, thalamus, hypothalamus, and the cerebral cortex.

Original languageEnglish
Pages (from-to)2826-2834
Number of pages9
JournalNanoscale
Volume2
Issue number12
DOIs
Publication statusPublished - Nov 2010

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Sousa, F., Mandal, S., Garrovo, C., Astolfo, A., Bonifacio, A., Latawiec, D., Menk, R. H., Arfelli, F., Huewel, S., Legname, G., Galla, H. J., & Krol, S. (2010). Functionalized gold nanoparticles: A detailed in vivo multimodal microscopic brain distribution study. Nanoscale, 2(12), 2826-2834. https://doi.org/10.1039/c0nr00345j