Functionally abnormal monocytes in hypercholesterolemia

Eduardo Stragliotto, Marina Camera, Alfredo Postiglione, Marina Sirtori, Giovanni Di Minno, Elena Tremoli

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We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p

Original languageEnglish
Pages (from-to)944-950
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number6
Publication statusPublished - 1993


  • Hypercholesterolemia
  • Leukotriene B
  • Monocytes
  • Superoxide anion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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