Functionally abnormal monocytes in hypercholesterolemia

Eduardo Stragliotto; Marina Camera; Alfredo Postiglione; Marina Sirtori; Giovanni Di Minno; Elena Tremoli

Functionally abnormal monocytes in hypercholesterolemia

Eduardo Stragliotto, Marina Camera, Alfredo Postiglione, Marina Sirtori, Giovanni Di Minno, Elena Tremoli

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B₂ in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E₂ and 6-ketoprostaglandin F_1α in response to these agonists was 1.5-3 times normal, and that of leukotriene B₄ was 40-60% of the normal value (p2 ^-, the extent of which was correlated with the impaired formation of leukotriene B₄. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p

Original language	English
Pages (from-to)	944-950
Number of pages	7
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	13
Issue number	6
Publication status	Published - 1993

Keywords

Hypercholesterolemia
Leukotriene B
Monocytes
Superoxide anion

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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abstract = "We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F1α in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p",

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author = "Eduardo Stragliotto and Marina Camera and Alfredo Postiglione and Marina Sirtori and Minno, {Giovanni Di} and Elena Tremoli",

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T1 - Functionally abnormal monocytes in hypercholesterolemia

AU - Stragliotto, Eduardo

AU - Camera, Marina

AU - Postiglione, Alfredo

AU - Sirtori, Marina

AU - Minno, Giovanni Di

AU - Tremoli, Elena

PY - 1993

Y1 - 1993

N2 - We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F1α in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p

AB - We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F1α in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p

KW - Hypercholesterolemia

KW - Leukotriene B

KW - Monocytes

KW - Superoxide anion

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Functionally abnormal monocytes in hypercholesterolemia

Abstract

Keywords

ASJC Scopus subject areas

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