Abstract
We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F1α in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p
| Original language | English |
|---|---|
| Pages (from-to) | 944-950 |
| Number of pages | 7 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 13 |
| Issue number | 6 |
| Publication status | Published - 1993 |
Fingerprint
Keywords
- Hypercholesterolemia
- Leukotriene B
- Monocytes
- Superoxide anion
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Functionally abnormal monocytes in hypercholesterolemia. / Stragliotto, Eduardo; Camera, Marina; Postiglione, Alfredo; Sirtori, Marina; Minno, Giovanni Di; Tremoli, Elena.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 13, No. 6, 1993, p. 944-950.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functionally abnormal monocytes in hypercholesterolemia
AU - Stragliotto, Eduardo
AU - Camera, Marina
AU - Postiglione, Alfredo
AU - Sirtori, Marina
AU - Minno, Giovanni Di
AU - Tremoli, Elena
PY - 1993
Y1 - 1993
N2 - We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F1α in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p
AB - We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F1α in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p
KW - Hypercholesterolemia
KW - Leukotriene B
KW - Monocytes
KW - Superoxide anion
UR - http://www.scopus.com/inward/record.url?scp=0027285008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027285008&partnerID=8YFLogxK
M3 - Article
C2 - 8388715
AN - SCOPUS:0027285008
VL - 13
SP - 944
EP - 950
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 6
ER -