Functionally abnormal monocytes in hypercholesterolemia

Eduardo Stragliotto, Marina Camera, Alfredo Postiglione, Marina Sirtori, Giovanni Di Minno, Elena Tremoli

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We investigated some functions of monocytes from 20 type lia hypercholesterolemic (HC) and five homozygous familial hypercholesterolemic (FH) patients. Monocytes from the HC patients contained as much cholesterol and formed as much thromboxane B2 in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) or calcium ionophore A23187 as those from normal individuals. In contrast, the generation of prostaglandin E2 and 6-ketoprostaglandin F in response to these agonists was 1.5-3 times normal, and that of leukotriene B4 was 40-60% of the normal value (p2 -, the extent of which was correlated with the impaired formation of leukotriene B4. On the other hand, adhesion studies indicated that patients' cells exhibited an abnormally high ability to adhere to glass (p

Original languageEnglish
Pages (from-to)944-950
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume13
Issue number6
Publication statusPublished - 1993

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Hypercholesterolemia
Monocytes
Leukotriene B4
N-Formylmethionine Leucyl-Phenylalanine
Thromboxane B2
Calcium Ionophores
Calcimycin
Dinoprostone
Glass
Reference Values
Cholesterol

Keywords

  • Hypercholesterolemia
  • Leukotriene B
  • Monocytes
  • Superoxide anion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Stragliotto, E., Camera, M., Postiglione, A., Sirtori, M., Minno, G. D., & Tremoli, E. (1993). Functionally abnormal monocytes in hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 13(6), 944-950.

Functionally abnormal monocytes in hypercholesterolemia. / Stragliotto, Eduardo; Camera, Marina; Postiglione, Alfredo; Sirtori, Marina; Minno, Giovanni Di; Tremoli, Elena.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 13, No. 6, 1993, p. 944-950.

Research output: Contribution to journalArticle

Stragliotto, E, Camera, M, Postiglione, A, Sirtori, M, Minno, GD & Tremoli, E 1993, 'Functionally abnormal monocytes in hypercholesterolemia', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 13, no. 6, pp. 944-950.
Stragliotto, Eduardo ; Camera, Marina ; Postiglione, Alfredo ; Sirtori, Marina ; Minno, Giovanni Di ; Tremoli, Elena. / Functionally abnormal monocytes in hypercholesterolemia. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1993 ; Vol. 13, No. 6. pp. 944-950.
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