Functionally active ganglioneuroma with increased plasma and urinary catecholamines and positive iodine 131-meta-iodobenzylguanidine scintigraphy

A. Clerico, A. Jenkner, M. A. Castello, G. Ciofetta, C. Lucarelli, M. Codini

Research output: Contribution to journalArticle

Abstract

Ganglioneuromas are usually considered not to be functionally active. Studies of their catecholamine excretory pattern and of their imaging by means of the adrenergic tracing agent 131-I-MIBG have been therefore sparse. We report on a case of secretory ganglioneuroma, as demonstrated by the increased urinary excretion of the catecholamine metabolities HVA and VMA, increased plasma dopamine and epinephrine levels, and positive 131-I-MIBG scintigraphy. We must therefore be aware that a functionally active tumor is not necessarily a neuroblastoma, and that the diagnosis should be biopsy proven.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalMedical and Pediatric Oncology
Volume19
Issue number4
Publication statusPublished - 1991

Keywords

  • 131-I-MIBG scintigraphy
  • Catecholamines
  • Ganglioneuroma
  • Plasma
  • Urine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Functionally active ganglioneuroma with increased plasma and urinary catecholamines and positive iodine 131-meta-iodobenzylguanidine scintigraphy'. Together they form a unique fingerprint.

  • Cite this