Functionally active ganglioneuroma with increased plasma and urinary catecholamines and positive iodine 131-meta-iodobenzylguanidine scintigraphy

A. Clerico, A. Jenkner, M. A. Castello, G. Ciofetta, C. Lucarelli, M. Codini

Research output: Contribution to journalArticlepeer-review

Abstract

Ganglioneuromas are usually considered not to be functionally active. Studies of their catecholamine excretory pattern and of their imaging by means of the adrenergic tracing agent 131-I-MIBG have been therefore sparse. We report on a case of secretory ganglioneuroma, as demonstrated by the increased urinary excretion of the catecholamine metabolities HVA and VMA, increased plasma dopamine and epinephrine levels, and positive 131-I-MIBG scintigraphy. We must therefore be aware that a functionally active tumor is not necessarily a neuroblastoma, and that the diagnosis should be biopsy proven.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalMedical and Pediatric Oncology
Volume19
Issue number4
Publication statusPublished - 1991

Keywords

  • 131-I-MIBG scintigraphy
  • Catecholamines
  • Ganglioneuroma
  • Plasma
  • Urine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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