Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro

Claudio Esposito, Andrea Masotti, Nicoletta Del Grosso, Daniela Malizia, Armandodoriano Bianco, Francesco Bonadies, Raffaella Napolitano, Giancarlo Ortaggi, Giuseppe Mossa

Research output: Contribution to journalArticle

Abstract

Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These liposomes are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MM54) show at specific charge ratios better transfection efficiency than that of some commercially available liposomes.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalComptes Rendus Chimie
Volume6
Issue number5-6
DOIs
Publication statusPublished - May 1 2003

Keywords

  • Cationic liposomes
  • Gene therapy
  • Glioma
  • pH-dependent lipids
  • Transfection

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro'. Together they form a unique fingerprint.

  • Cite this

    Esposito, C., Masotti, A., Del Grosso, N., Malizia, D., Bianco, A., Bonadies, F., Napolitano, R., Ortaggi, G., & Mossa, G. (2003). Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro. Comptes Rendus Chimie, 6(5-6), 617-622. https://doi.org/10.1016/S1631-0748(03)00085-7