Fundus autofluorescence patterns in best vitelliform macular dystrophy

Maurizio Battaglia Parodi, Pierluigi Iacono, Claudio Campa, Claudia Del Turco, Francesco Bandello

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: To provide a systematic classification of fundus autofluorescence (FAF) patterns in patients affected by Best vitelliform macular dystrophy.

Design: Cross-sectional prospective study.

Methods: Patients affected by Best vitelliformmacular dystrophy at different stages of the disease were prospectively enrolled from January 2012 to July 2013. Eighty eyes of 40 patients were included in the study. All patients underwent a complete ophthalmologic examination, including genetic characterization, short-wavelength FAF, and near-infrared FAF. Main outcome measures were the recognition of the FAF patterns in the different stages and the identification of a relationship between FAF patterns and best-corrected visual acuity (BCVA).

Results: Six FAF patterns for both short-wavelength and near-infrared FAF were identified, including normal, hyper-autofluorescent, hypo-autofluorescent, patchy, multifocal, and spoke-like patterns.ApplyingGasss classification for defining consecutive stages of Best vitelliform macular dystrophy (namely vitelliform, pseudohypopyon, vitelliruptive, atrophic, and cicatricial) identified no pattern as stage-specific. Patchy patterns had the highest prevalence. A statistically significant difference (Kruskal- Wallis ANOVA) was found among hyperautofluorescent, patchy, and hypo-autofluorescent patterns, both in short-wavelength (P = .001) and nearinfrared FAF (P = .001). Hyper-autofluorescent and hypo-autofluorescent patterns were associated with better and worse BCVA, respectively.

Conclusion: Six main patterns on both shortwavelength and near-infrared FAF were identified in Best vitelliform macular dystrophy.NoFAFpattern can be considered stage-specific. Although a difference in the BCVA among the FAF patterns was registered, only a longitudinal study designed to evaluate the clinical and FAF modifications over the follow-up will help clarify the prognostic implications of each FAF pattern.

Original languageEnglish
Pages (from-to)1086-1092
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume158
Issue number5
DOIs
Publication statusPublished - Nov 1 2014

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Vitelliform Macular Dystrophy
Visual Acuity
Longitudinal Studies
Analysis of Variance
Cross-Sectional Studies
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Fundus autofluorescence patterns in best vitelliform macular dystrophy. / Parodi, Maurizio Battaglia; Iacono, Pierluigi; Campa, Claudio; Del Turco, Claudia; Bandello, Francesco.

In: American Journal of Ophthalmology, Vol. 158, No. 5, 01.11.2014, p. 1086-1092.

Research output: Contribution to journalArticle

Parodi, Maurizio Battaglia ; Iacono, Pierluigi ; Campa, Claudio ; Del Turco, Claudia ; Bandello, Francesco. / Fundus autofluorescence patterns in best vitelliform macular dystrophy. In: American Journal of Ophthalmology. 2014 ; Vol. 158, No. 5. pp. 1086-1092.
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abstract = "Purpose: To provide a systematic classification of fundus autofluorescence (FAF) patterns in patients affected by Best vitelliform macular dystrophy.Design: Cross-sectional prospective study.Methods: Patients affected by Best vitelliformmacular dystrophy at different stages of the disease were prospectively enrolled from January 2012 to July 2013. Eighty eyes of 40 patients were included in the study. All patients underwent a complete ophthalmologic examination, including genetic characterization, short-wavelength FAF, and near-infrared FAF. Main outcome measures were the recognition of the FAF patterns in the different stages and the identification of a relationship between FAF patterns and best-corrected visual acuity (BCVA).Results: Six FAF patterns for both short-wavelength and near-infrared FAF were identified, including normal, hyper-autofluorescent, hypo-autofluorescent, patchy, multifocal, and spoke-like patterns.ApplyingGasss classification for defining consecutive stages of Best vitelliform macular dystrophy (namely vitelliform, pseudohypopyon, vitelliruptive, atrophic, and cicatricial) identified no pattern as stage-specific. Patchy patterns had the highest prevalence. A statistically significant difference (Kruskal- Wallis ANOVA) was found among hyperautofluorescent, patchy, and hypo-autofluorescent patterns, both in short-wavelength (P = .001) and nearinfrared FAF (P = .001). Hyper-autofluorescent and hypo-autofluorescent patterns were associated with better and worse BCVA, respectively.Conclusion: Six main patterns on both shortwavelength and near-infrared FAF were identified in Best vitelliform macular dystrophy.NoFAFpattern can be considered stage-specific. Although a difference in the BCVA among the FAF patterns was registered, only a longitudinal study designed to evaluate the clinical and FAF modifications over the follow-up will help clarify the prognostic implications of each FAF pattern.",
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