INFEZIONI FUNGINE IN ONCOLOGIA PEDIATRICA

Translated title of the contribution: Fungal infections in children with cancer

L. Manfredini, A. Garaventa, E. Castagnola, C. Viscoli, C. Moroni, G. Dini, M. L. Garre, G. Manno, C. Savioli, Z. Kotitsa, M. A. Barretta, L. Massimo

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical charts of cancer patients with documented fungal infections hospitalized at G. Gaslini Children's Hospital, Italy, from 1980 to 1990 were reviewed. Thirty-seven episodes developing in 37 patients were identified, based on microbiological and/or histological documentation. Patients' age ranged from 3 months to 18 years (median 7 years). Twenty patients were treated for hematological malignancy and 17 had solid tumor. Seven patients (3 with leukemia and 4 with solid tumours), developed mycosis after bone marrow transplantation procedure. A history of neutropenia in the month preceding the documentation of fungal infection was present in 76% still neutropenic at time of diagnosis. In 40% of the cases the fungal infection developed as primary infection not preceded by any febrile and/or infectious episode. Fungemias without evident organ localization accounted for the 40% of episodes with a mortality rate of 20%. The other 22 cases (60%) were classified as invasive mycoses; 9 of these patients died (41%). Mortality was higher among patients with mold infection (5 of 7, 72%), than in those with yeast infection (7 of 29, 24%). Mold infections and invasive mycoses were virtually absent in the first part of our period of observation (1980-84), but emerged in the second period (1985-90) when also the incidence rate of fungal disease increased (from 2.67/10,000 person/day to 5.93), probably in relation with extensive construction works and with the implementation of a bone marrow transplantation program.

Translated title of the contributionFungal infections in children with cancer
Original languageItalian
Pages (from-to)435-441
Number of pages7
JournalPediatria Medica e Chirurgica
Volume17
Issue number5
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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