TY - JOUR
T1 - Further evidence of MAO-A gene variants associated with bipolar disorder
AU - Müller, Daniel J.
AU - Serretti, Alessandro
AU - Sicard, Tricia
AU - Tharmalingain, Subi
AU - King, Nicole
AU - Artioli, Paola
AU - Mandelli, Laura
AU - Lorenzi, Cristina
AU - Kennedy, James L.
PY - 2007/1/5
Y1 - 2007/1/5
N2 - The aim of this study was to investigate MAOA gene variants in bipolar disorder by using a family-based association approach. The first sample included 331 nuclear families from Western and Central Canada with at least 1 offspring affected with bipolar disorder comprising a total of 1,044 individuals. All subjects were genotyped for MAOA-941T > G and -uVNTR gene variants using PCR techniques. Haplotype TDT was statistically significant (LRS = 12.17; df = 3; P = 0.0088; permutation global significance = 0.00098), with the T-4 haplotype significantly associated with bipolar disorder (OR = 1.63, 95% CI = 1.11-2.37). Single marker analysis evidenced a borderline association for MAOA-941T > G (P = 0.04), but not for the uVNTR. Pooling the Canadian sample with a second previously reported Italian sample genotyped for the uVNTR variant, negative results were obtained as well. No different results were detected when analyzing female subjects separately. In conclusion, our family-based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder.
AB - The aim of this study was to investigate MAOA gene variants in bipolar disorder by using a family-based association approach. The first sample included 331 nuclear families from Western and Central Canada with at least 1 offspring affected with bipolar disorder comprising a total of 1,044 individuals. All subjects were genotyped for MAOA-941T > G and -uVNTR gene variants using PCR techniques. Haplotype TDT was statistically significant (LRS = 12.17; df = 3; P = 0.0088; permutation global significance = 0.00098), with the T-4 haplotype significantly associated with bipolar disorder (OR = 1.63, 95% CI = 1.11-2.37). Single marker analysis evidenced a borderline association for MAOA-941T > G (P = 0.04), but not for the uVNTR. Pooling the Canadian sample with a second previously reported Italian sample genotyped for the uVNTR variant, negative results were obtained as well. No different results were detected when analyzing female subjects separately. In conclusion, our family-based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder.
KW - Affective disorder
KW - Bipolar disorder
KW - Genetics
KW - MAO-A
UR - http://www.scopus.com/inward/record.url?scp=33846277959&partnerID=8YFLogxK
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U2 - 10.1002/ajmg.b.30380
DO - 10.1002/ajmg.b.30380
M3 - Article
C2 - 16958037
AN - SCOPUS:33846277959
VL - 144
SP - 37
EP - 40
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 1
ER -