Further evidence of MAO-A gene variants associated with bipolar disorder

Daniel J. Müller, Alessandro Serretti, Tricia Sicard, Subi Tharmalingain, Nicole King, Paola Artioli, Laura Mandelli, Cristina Lorenzi, James L. Kennedy

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate MAOA gene variants in bipolar disorder by using a family-based association approach. The first sample included 331 nuclear families from Western and Central Canada with at least 1 offspring affected with bipolar disorder comprising a total of 1,044 individuals. All subjects were genotyped for MAOA-941T > G and -uVNTR gene variants using PCR techniques. Haplotype TDT was statistically significant (LRS = 12.17; df = 3; P = 0.0088; permutation global significance = 0.00098), with the T-4 haplotype significantly associated with bipolar disorder (OR = 1.63, 95% CI = 1.11-2.37). Single marker analysis evidenced a borderline association for MAOA-941T > G (P = 0.04), but not for the uVNTR. Pooling the Canadian sample with a second previously reported Italian sample genotyped for the uVNTR variant, negative results were obtained as well. No different results were detected when analyzing female subjects separately. In conclusion, our family-based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume144
Issue number1
DOIs
Publication statusPublished - Jan 5 2007

Keywords

  • Affective disorder
  • Bipolar disorder
  • Genetics
  • MAO-A

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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  • Cite this

    Müller, D. J., Serretti, A., Sicard, T., Tharmalingain, S., King, N., Artioli, P., Mandelli, L., Lorenzi, C., & Kennedy, J. L. (2007). Further evidence of MAO-A gene variants associated with bipolar disorder. American Journal of Medical Genetics - Neuropsychiatric Genetics, 144(1), 37-40. https://doi.org/10.1002/ajmg.b.30380