Further evidence that brain histamine H2 receptors are stimulatory in the control of prolactin in the rat

C. Netti, V. Sibilia, F. Guidobono, I. Villa, P. Franco, A. Pecile

Research output: Contribution to journalArticle

Abstract

The effects of administration into the brain ventricle of H2 receptor agonists (4-methylhistamine, 0.8 μmol/rat; dimaprit, 0.4-0.8 μmol/rat), H2 antagonists (cimetidine, 0.8 μmol/rat; ranitidine, 0.4-0.8 μmol/rat; famotidine, 0.03 μmol/rat) and of the dimaprit chemical analogue SK&F 91487 (0.4 μmol/rat) on unstimulated and histamine-stimulated prolactin secretion in normal male rats were studied. The H2 agonist 4-methylhistamine caused a significant increase in unstimulated blood PRL, whereas dimaprit, SK&F 91487, and the H2 antagonists tested did not change PRL levels. 4-Methylhistamine significantly enhanced the stimulatory effects of histamine on prolactin, whereas all the H2 antagonists inhibited histamine-induced prolactin release. The inhibition of histamine-induced prolactin secretion by the H2 agonist dimaprit is nonspecific, since its chemical analogue SK&F 91487, which has no H2 agonist activity, also inhibits it. These results indicate that stimulation of the H2 receptors in the central nervous system is facilitatory for PRL secretion, suggesting that the activation of H2 receptors may contribute to the PFL-releasing effects of histamine.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalActa Endocrinologica
Volume119
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Endocrinology

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    Netti, C., Sibilia, V., Guidobono, F., Villa, I., Franco, P., & Pecile, A. (1988). Further evidence that brain histamine H2 receptors are stimulatory in the control of prolactin in the rat. Acta Endocrinologica, 119(4), 488-492.