Further observations on the interactions between phenobarbital and diphenyl-hydantoin during chronic treatment in the rat

M. Rizzo; P. L. Morselli; S. Garattini

doi:10.1016/0006-2952(72)90317-6

Further observations on the interactions between phenobarbital and diphenyl-hydantoin during chronic treatment in the rat

M. Rizzo, P. L. Morselli, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Levels of diphenylhydantoin (DPH) and phenobarbital (PB) in plasma and brain of rats after single or combined, acute or chronic treatment have been determined. The results obtained indicate (a) drug plasma levels are not always a reliable index of brain levels because DPH disappearance from plasma is frequently more rapid than from brain; (b) DPH administration enhances the plasma and brain levels of PB; (c) levels of DPH or PB in brain correlate with the protection against a maximal electroshock.

Original language	English
Pages (from-to)	449-454
Number of pages	6
Journal	Biochemical Pharmacology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0006-2952(72)90317-6
Publication status	Published - Feb 15 1972

ASJC Scopus subject areas

Pharmacology

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10.1016/0006-2952(72)90317-6

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abstract = "Levels of diphenylhydantoin (DPH) and phenobarbital (PB) in plasma and brain of rats after single or combined, acute or chronic treatment have been determined. The results obtained indicate (a) drug plasma levels are not always a reliable index of brain levels because DPH disappearance from plasma is frequently more rapid than from brain; (b) DPH administration enhances the plasma and brain levels of PB; (c) levels of DPH or PB in brain correlate with the protection against a maximal electroshock.",

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AU - Garattini, S.

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AB - Levels of diphenylhydantoin (DPH) and phenobarbital (PB) in plasma and brain of rats after single or combined, acute or chronic treatment have been determined. The results obtained indicate (a) drug plasma levels are not always a reliable index of brain levels because DPH disappearance from plasma is frequently more rapid than from brain; (b) DPH administration enhances the plasma and brain levels of PB; (c) levels of DPH or PB in brain correlate with the protection against a maximal electroshock.

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Further observations on the interactions between phenobarbital and diphenyl-hydantoin during chronic treatment in the rat

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