Further observations on the interactions between phenobarbital and diphenyl-hydantoin during chronic treatment in the rat

M. Rizzo, P. L. Morselli, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Levels of diphenylhydantoin (DPH) and phenobarbital (PB) in plasma and brain of rats after single or combined, acute or chronic treatment have been determined. The results obtained indicate (a) drug plasma levels are not always a reliable index of brain levels because DPH disappearance from plasma is frequently more rapid than from brain; (b) DPH administration enhances the plasma and brain levels of PB; (c) levels of DPH or PB in brain correlate with the protection against a maximal electroshock.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalBiochemical Pharmacology
Volume21
Issue number4
DOIs
Publication statusPublished - Feb 15 1972

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Further observations on the interactions between phenobarbital and diphenyl-hydantoin during chronic treatment in the rat'. Together they form a unique fingerprint.

Cite this