Abstract
Adriamycin (AM)-induced lipid peroxidation was studied in rat liver microsomal system, measuring colour produced by thiobarbituric acid (TBA) reactive material and the development of volatile hydrocarbons. The onset of this degradative process is closely related to the AM content. This phenomenon appears to be highly influenced by the buffer used for the microsomal preparation. The effect of AM on Fe-ADP-induced lipid peroxidation in liver microsomes has also been studied.
| Original language | English |
|---|---|
| Pages (from-to) | 357-367 |
| Number of pages | 11 |
| Journal | Chemico-Biological Interactions |
| Volume | 38 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1982 |
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ASJC Scopus subject areas
- Toxicology
Cite this
Further studies on adriamycin induced in vitro lipid peroxidation. / Facchinetti, T.; Müh-Zange, M.; Salmona, M.; Carini, M.; Remmer, H.
In: Chemico-Biological Interactions, Vol. 38, No. 3, 1982, p. 357-367.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Further studies on adriamycin induced in vitro lipid peroxidation
AU - Facchinetti, T.
AU - Müh-Zange, M.
AU - Salmona, M.
AU - Carini, M.
AU - Remmer, H.
PY - 1982
Y1 - 1982
N2 - Adriamycin (AM)-induced lipid peroxidation was studied in rat liver microsomal system, measuring colour produced by thiobarbituric acid (TBA) reactive material and the development of volatile hydrocarbons. The onset of this degradative process is closely related to the AM content. This phenomenon appears to be highly influenced by the buffer used for the microsomal preparation. The effect of AM on Fe-ADP-induced lipid peroxidation in liver microsomes has also been studied.
AB - Adriamycin (AM)-induced lipid peroxidation was studied in rat liver microsomal system, measuring colour produced by thiobarbituric acid (TBA) reactive material and the development of volatile hydrocarbons. The onset of this degradative process is closely related to the AM content. This phenomenon appears to be highly influenced by the buffer used for the microsomal preparation. The effect of AM on Fe-ADP-induced lipid peroxidation in liver microsomes has also been studied.
UR - http://www.scopus.com/inward/record.url?scp=0020044607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020044607&partnerID=8YFLogxK
U2 - 10.1016/0009-2797(82)90065-5
DO - 10.1016/0009-2797(82)90065-5
M3 - Article
C2 - 7060215
AN - SCOPUS:0020044607
VL - 38
SP - 357
EP - 367
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
SN - 0009-2797
IS - 3
ER -