Abstract
The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.
| Original language | English |
|---|---|
| Pages (from-to) | 253-256 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1970 |
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Keywords
- Diazepam metabolism
- Mouse
- N-demethyldiazepam
- N-methyloxazepam
- Oxazepam
- Rat
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Further studies on species difference in diazepam metabolism. / Marcucci, F.; Fanelli, R.; Mussini, E.; Garattini, S.
In: European Journal of Pharmacology, Vol. 9, No. 2, 1970, p. 253-256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Further studies on species difference in diazepam metabolism
AU - Marcucci, F.
AU - Fanelli, R.
AU - Mussini, E.
AU - Garattini, S.
PY - 1970
Y1 - 1970
N2 - The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.
AB - The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.
KW - Diazepam metabolism
KW - Mouse
KW - N-demethyldiazepam
KW - N-methyloxazepam
KW - Oxazepam
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0014743926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014743926&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(70)90308-0
DO - 10.1016/0014-2999(70)90308-0
M3 - Article
VL - 9
SP - 253
EP - 256
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -