Abstract
The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.
| Original language | English |
|---|---|
| Pages (from-to) | 253-256 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1970 |
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Keywords
- Diazepam metabolism
- Mouse
- N-demethyldiazepam
- N-methyloxazepam
- Oxazepam
- Rat
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Marcucci, F., Fanelli, R., Mussini, E., & Garattini, S. (1970). Further studies on species difference in diazepam metabolism. European Journal of Pharmacology, 9(2), 253-256. https://doi.org/10.1016/0014-2999(70)90308-0