Further studies on species difference in diazepam metabolism

F. Marcucci, R. Fanelli, E. Mussini, S. Garattini

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalEuropean Journal of Pharmacology
Volume9
Issue number2
DOIs
Publication statusPublished - 1970

Fingerprint

Diazepam
Oxazepam
Anticonvulsants
Brain
Temazepam
Intravenous Administration
Adipose Tissue

Keywords

  • Diazepam metabolism
  • Mouse
  • N-demethyldiazepam
  • N-methyloxazepam
  • Oxazepam
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Further studies on species difference in diazepam metabolism. / Marcucci, F.; Fanelli, R.; Mussini, E.; Garattini, S.

In: European Journal of Pharmacology, Vol. 9, No. 2, 1970, p. 253-256.

Research output: Contribution to journalArticle

@article{8a9e4964124c4949b44afda0654c8486,
title = "Further studies on species difference in diazepam metabolism",
abstract = "The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.",
keywords = "Diazepam metabolism, Mouse, N-demethyldiazepam, N-methyloxazepam, Oxazepam, Rat",
author = "F. Marcucci and R. Fanelli and E. Mussini and S. Garattini",
year = "1970",
doi = "10.1016/0014-2999(70)90308-0",
language = "English",
volume = "9",
pages = "253--256",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Further studies on species difference in diazepam metabolism

AU - Marcucci, F.

AU - Fanelli, R.

AU - Mussini, E.

AU - Garattini, S.

PY - 1970

Y1 - 1970

N2 - The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.

AB - The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.

KW - Diazepam metabolism

KW - Mouse

KW - N-demethyldiazepam

KW - N-methyloxazepam

KW - Oxazepam

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0014743926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014743926&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(70)90308-0

DO - 10.1016/0014-2999(70)90308-0

M3 - Article

VL - 9

SP - 253

EP - 256

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -