Further studies on species difference in diazepam metabolism

F. Marcucci, R. Fanelli, E. Mussini, S. Garattini

Research output: Contribution to journalArticle

Abstract

The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalEuropean Journal of Pharmacology
Volume9
Issue number2
DOIs
Publication statusPublished - 1970

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Keywords

  • Diazepam metabolism
  • Mouse
  • N-demethyldiazepam
  • N-methyloxazepam
  • Oxazepam
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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