Further studies on species difference in diazepam metabolism

F. Marcucci; R. Fanelli; E. Mussini; S. Garattini

doi:10.1016/0014-2999(70)90308-0

Further studies on species difference in diazepam metabolism

F. Marcucci, R. Fanelli, E. Mussini, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.

Original language	English
Pages (from-to)	253-256
Number of pages	4
Journal	European Journal of Pharmacology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(70)90308-0
Publication status	Published - 1970

Keywords

Diazepam metabolism
Mouse
N-demethyldiazepam
N-methyloxazepam
Oxazepam
Rat

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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abstract = "The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.",

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T1 - Further studies on species difference in diazepam metabolism

AU - Marcucci, F.

AU - Fanelli, R.

AU - Mussini, E.

AU - Garattini, S.

PY - 1970

Y1 - 1970

N2 - The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.

AB - The anticonvulsant activity of diazepam lasts longer in mice than in rats. The brain levels of diazepam are similar in both species but N-demethyl diazepam and oxazepam accumulate in mouse brain while they are practically undetectable in rat brain. This difference occurs also in blood and adipose tissue. N-methyloxazepam was not detected in rats or mice after an intravenous administration of diazepam. It is suggested that the N-methyl diazepam and oxazepam formed in mice may be responsible for the prolonged anticonvulsant action of diazepam in this species.

KW - Diazepam metabolism

KW - Mouse

KW - N-demethyldiazepam

KW - N-methyloxazepam

KW - Oxazepam

KW - Rat

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Further studies on species difference in diazepam metabolism

Abstract

Keywords

ASJC Scopus subject areas

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