Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life

S. Sonnino, R. Bassi, V. Chigorno, G. Tettamanti

Research output: Contribution to journalArticlepeer-review

Abstract

The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.

Original languageEnglish
Pages (from-to)1653-1660
Number of pages8
JournalJournal of Neurochemistry
Volume54
Issue number5
Publication statusPublished - 1990

Keywords

  • Age
  • Brain
  • Development
  • Fatty acids
  • Gangliosides
  • Long-chain bases

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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