Abstract
The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.
| Original language | English |
|---|---|
| Pages (from-to) | 1653-1660 |
| Number of pages | 8 |
| Journal | Journal of Neurochemistry |
| Volume | 54 |
| Issue number | 5 |
| Publication status | Published - 1990 |
Keywords
- Age
- Brain
- Development
- Fatty acids
- Gangliosides
- Long-chain bases
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience