Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life

S. Sonnino, R. Bassi, V. Chigorno, G. Tettamanti

Research output: Contribution to journalArticle

Abstract

The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.

Original languageEnglish
Pages (from-to)1653-1660
Number of pages8
JournalJournal of Neurochemistry
Volume54
Issue number5
Publication statusPublished - 1990

Fingerprint

Gangliosides
Chickens
Brain
Carbon
Densitometry
Ceramides
Alkalies
Chromatography
Fatty Acids

Keywords

  • Age
  • Brain
  • Development
  • Fatty acids
  • Gangliosides
  • Long-chain bases

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Sonnino, S., Bassi, R., Chigorno, V., & Tettamanti, G. (1990). Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life. Journal of Neurochemistry, 54(5), 1653-1660.

Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life. / Sonnino, S.; Bassi, R.; Chigorno, V.; Tettamanti, G.

In: Journal of Neurochemistry, Vol. 54, No. 5, 1990, p. 1653-1660.

Research output: Contribution to journalArticle

Sonnino, S, Bassi, R, Chigorno, V & Tettamanti, G 1990, 'Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life', Journal of Neurochemistry, vol. 54, no. 5, pp. 1653-1660.
Sonnino, S. ; Bassi, R. ; Chigorno, V. ; Tettamanti, G. / Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life. In: Journal of Neurochemistry. 1990 ; Vol. 54, No. 5. pp. 1653-1660.
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