Abstract
The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.
| Original language | English |
|---|---|
| Pages (from-to) | 1653-1660 |
| Number of pages | 8 |
| Journal | Journal of Neurochemistry |
| Volume | 54 |
| Issue number | 5 |
| Publication status | Published - 1990 |
Fingerprint
Keywords
- Age
- Brain
- Development
- Fatty acids
- Gangliosides
- Long-chain bases
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
Cite this
Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life. / Sonnino, S.; Bassi, R.; Chigorno, V.; Tettamanti, G.
In: Journal of Neurochemistry, Vol. 54, No. 5, 1990, p. 1653-1660.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life
AU - Sonnino, S.
AU - Bassi, R.
AU - Chigorno, V.
AU - Tettamanti, G.
PY - 1990
Y1 - 1990
N2 - The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.
AB - The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.
KW - Age
KW - Brain
KW - Development
KW - Fatty acids
KW - Gangliosides
KW - Long-chain bases
UR - http://www.scopus.com/inward/record.url?scp=0025230661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025230661&partnerID=8YFLogxK
M3 - Article
C2 - 2324741
AN - SCOPUS:0025230661
VL - 54
SP - 1653
EP - 1660
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 5
ER -