Further studies on the effects of chronic clozapine on regional extracellular dopamine levels in the brain of conscious rats

Roberto Invernizzi, Laura Pozzi, Rosario Samanin

Research output: Contribution to journalArticle

Abstract

The effect of chronic oral treatment with clozapine (20 mg/kg daily for 21 days) on the extracellular concentrations of dopamine, dihydroxyphenylacetic acid and homovanillic acid in the dorsolateral anterior striatum, nucleus accumbens and frontal cortex was studied by microdialysis in conscious rats. Basal levels of dopamine and its metabolites in the three brain regions of rats treated chronically with clozapine were not significantly different from those of vehicle-treated rats. A subcutaneous challenge dose of clozapine (20 mg/kg) significantly increased the extracellular concentrations of dopamine and its metabolites in the three brain regions, with no differences between chronic vehicle- and clozapine-treated rats.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalBrain Research
Volume670
Issue number1
DOIs
Publication statusPublished - Jan 23 1995

Keywords

  • Brain microdialysis
  • Chronic treatment
  • Clozapine
  • Dopamine release

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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