Future challenges in head and neck cancer

From the bench to the bedside?

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50%. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume84
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Dec 1 2012

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Head and Neck Neoplasms
Tobacco Use
Alcohols
Carcinoma
Mortality
Incidence
Infection
Population
Neoplasms
Therapeutics

Keywords

  • Challenges
  • Diagnosis
  • Head neck oncology
  • Medical oncology
  • Prevention
  • Radiation oncology
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

Cite this

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title = "Future challenges in head and neck cancer: From the bench to the bedside?",
abstract = "HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50{\%}. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.",
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author = "Luca Calabrese and Angelo Ostuni and Mohssen Ansarin and Gioacchino Giugliano and Fausto Maffini and Daniela Alterio and Rocca, {Maria Cossu} and Giuseppe Petralia and Roberto Bruschini and Fausto Chiesa",
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T1 - Future challenges in head and neck cancer

T2 - From the bench to the bedside?

AU - Calabrese, Luca

AU - Ostuni, Angelo

AU - Ansarin, Mohssen

AU - Giugliano, Gioacchino

AU - Maffini, Fausto

AU - Alterio, Daniela

AU - Rocca, Maria Cossu

AU - Petralia, Giuseppe

AU - Bruschini, Roberto

AU - Chiesa, Fausto

PY - 2012/12/1

Y1 - 2012/12/1

N2 - HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50%. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.

AB - HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50%. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.

KW - Challenges

KW - Diagnosis

KW - Head neck oncology

KW - Medical oncology

KW - Prevention

KW - Radiation oncology

KW - Surgery

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