Future challenges in head and neck cancer: From the bench to the bedside?

Research output: Contribution to journalArticlepeer-review


HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50%. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Issue numberSUPPL. 1
Publication statusPublished - Dec 1 2012


  • Challenges
  • Diagnosis
  • Head neck oncology
  • Medical oncology
  • Prevention
  • Radiation oncology
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology


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