TY - JOUR
T1 - Future challenges in head and neck cancer
T2 - From the bench to the bedside?
AU - Calabrese, Luca
AU - Ostuni, Angelo
AU - Ansarin, Mohssen
AU - Giugliano, Gioacchino
AU - Maffini, Fausto
AU - Alterio, Daniela
AU - Rocca, Maria Cossu
AU - Petralia, Giuseppe
AU - Bruschini, Roberto
AU - Chiesa, Fausto
PY - 2012/12/1
Y1 - 2012/12/1
N2 - HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50%. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.
AB - HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50%. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.
KW - Challenges
KW - Diagnosis
KW - Head neck oncology
KW - Medical oncology
KW - Prevention
KW - Radiation oncology
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=84871684424&partnerID=8YFLogxK
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U2 - 10.1016/j.critrevonc.2010.11.001
DO - 10.1016/j.critrevonc.2010.11.001
M3 - Article
C2 - 21145755
AN - SCOPUS:84871684424
VL - 84
SP - 90
EP - 96
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
IS - SUPPL. 1
ER -