Future challenges in head and neck cancer: From the bench to the bedside?

Luca Calabrese; Angelo Ostuni; Mohssen Ansarin; Gioacchino Giugliano; Fausto Maffini; Daniela Alterio; Maria Cossu Rocca; Giuseppe Petralia; Roberto Bruschini; Fausto Chiesa

doi:10.1016/j.critrevonc.2010.11.001

Future challenges in head and neck cancer: From the bench to the bedside?

Luca Calabrese, Angelo Ostuni, Mohssen Ansarin, Gioacchino Giugliano, Fausto Maffini, Daniela Alterio, Maria Cossu Rocca, Giuseppe Petralia, Roberto Bruschini, Fausto Chiesa

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article

Abstract

HNC is the 11th most frequent carcinoma with a world-wide yearly incidence exceeding over half a million cases [1], a 10:1 male gender predilection and country specific variability [2]. The principal risk factors are tobacco and alcohol use and, in a growing population without these exposures, HPV infection.While much progress has been made in understanding the molecular basis of cancer, the 5-year mortality of head and neck cancer has remained approximately 50%. To this date we have not been able to translate as much of our basic science knowledge into significant disease altering therapeutic strategies in terms of local, loco-regional, functional and overall survival. Challenges remain in all aspects of head and neck cancer management: prevention, diagnosis, surgical and non-surgical treatment.

Original language	English
Pages (from-to)	90-96
Number of pages	7
Journal	Critical Reviews in Oncology/Hematology
Volume	84
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/j.critrevonc.2010.11.001
Publication status	Published - Dec 1 2012

Keywords

Challenges
Diagnosis
Head neck oncology
Medical oncology
Prevention
Radiation oncology
Surgery

ASJC Scopus subject areas

Oncology
Hematology
Geriatrics and Gerontology

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Calabrese, L., Ostuni, A., Ansarin, M., Giugliano, G., Maffini, F., Alterio, D., Rocca, M. C., Petralia, G., Bruschini, R., & Chiesa, F. (2012). Future challenges in head and neck cancer: From the bench to the bedside? Critical Reviews in Oncology/Hematology, 84(SUPPL. 1), 90-96. https://doi.org/10.1016/j.critrevonc.2010.11.001

Future challenges in head and neck cancer : From the bench to the bedside? / Calabrese, Luca; Ostuni, Angelo; Ansarin, Mohssen ; Giugliano, Gioacchino ; Maffini, Fausto ; Alterio, Daniela ; Rocca, Maria Cossu ; Petralia, Giuseppe ; Bruschini, Roberto; Chiesa, Fausto.

In: Critical Reviews in Oncology/Hematology, Vol. 84, No. SUPPL. 1, 01.12.2012, p. 90-96.

Research output: Contribution to journal › Article

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