Future scenarios for the treatment of advanced non-small cell lung cancer: Focus on taxane-containing regimens

Francesco Grossi, Kaoru Kubota, Federico Cappuzzo, Filippo De Marinis, Cesare Gridelli, Marianna Aita, Jean Yves Douillard

Research output: Contribution to journalArticlepeer-review

Abstract

Despite recent progress in the development of new molecularly targeted agents, the chemotherapy regimens considered standard at the end of the last century-that is, two-drug combinations consisting of either cisplatin or carboplatin plus a third-generation agent (docetaxel, paclitaxel, gemcitabine, or vinorelbine)-remain the primary treatment option for advanced non-small cell lung cancer (NSCLC) patients. Most recently, the existing standard of care has been amended to reflect the significant survival advantage of cisplatin-pemetrexed over cisplatin- gemcitabine as first-line treatment of nonsquamous NSCLC. The addition of a biological drug (bevacizumab, cetuximab) or the use of a singleagent epidermal growth factor receptor inhibitor may further improve outcomes in selected patients. It has become increasingly clear, primarily through recent meta-analyses, that although the therapeutic equivalence of any combination of a platinum agent plus either gemcitabine, vinorelbine, docetaxel, or paclitaxel has been long accepted, each regimen has different side effects and therapeutic outcomes that allow clinicians to select the most appropriate treatment for chemotherapy- naïve patients with stage IIIB/IV NSCLC. In this review, we evaluate the available evidence and explore the role and importance of various modern chemotherapy regimens, with the aim of optimizing treatment selection and combination with biological agents. Emphasis is placed on the role of taxanes (docetaxel versus paclitaxel) in this changing landscape.

Original languageEnglish
Pages (from-to)1102-1112
Number of pages11
JournalThe oncologist
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Chemotherapy
  • Docetaxel
  • Non-small cell lung carcinoma
  • Treatment algorithm

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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