FV HR2 haplotype as additional inherited risk factor for deep vein thrombosis in individuals with a high-risk profile

Maurizio Margaglione, Anna Bossone, Donatello Coalizzo, Giovanna D'Andrea, Vincenzo Brancaccio, Antonio Ciampa, Elvira Grandone, Giovanni Di Minno

Research output: Contribution to journalArticlepeer-review

Abstract

A number of strongly linked polymorphisms within the Factor V gene (FV HR2 haplotype) has been identified as a cause of resistance to activated protein C, and has suggested a modest risk factor for vein thrombosis. We investigated the frequency of the HR2 haplotype in 433 consecutive patients with confirmed deep vein thrombosis and 326 controls. The HR2 haplotype was more frequent in patients (15.2%) than in controls (10.1%). The risk of thrombosis among carriers of this haplotype was significantly increased (odds ratio: 1.6 [95% CI: 1.0-2.5]). The estimated risk associated with the HR2 haplotype was 1.8 (95% CI: 1.1-2.9) in subjects with (n = 255), and 1.4 (95% CI: 0.8-2.4) in those without (n = 178) acquired risk factors for vein thrombosis. After adjustment for sex, FV Leiden and FII A20210 mutations, the estimated risk of vein thrombosis among carriers of the HR2 haplotype was 1.8 (95% CI: 1.1-2.8). Present data indicate that the HR2 haplotype is independently associated with vein thrombosis among individuals with a high-risk profile.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalThrombosis and Haemostasis
Volume87
Issue number1
Publication statusPublished - 2002

Keywords

  • FV gene
  • HR2 haplotype
  • Inherited risk factors
  • Vein thrombosis

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'FV HR2 haplotype as additional inherited risk factor for deep vein thrombosis in individuals with a high-risk profile'. Together they form a unique fingerprint.

Cite this