FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III

C. J C Addobbati, C. J C Addobbati, J. de AzevêDo Silva, N. A C Tavares, J. Araújo, R. L. Guimarães, R. L. Guimarães, L. Brandão, L. Brandão, S. Crovella, S. Crovella, P. Sandrin-Garcia, P. Sandrin-Garcia

Research output: Contribution to journalArticle

Abstract

The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. We also assessed the role of FYB SNPs in the insurgence of autoimmune polyglandular syndrome type III (APSIII), characterized by the simultaneous presence of autoimmune thyroid disease and celiac disease, in patients with T1DM from a Northeastern Brazilian population. One hundred and seventy-seven patients with T1DM and 190 healthy individuals were genotyped for seven tag SNPs, covering most of the FYB locus, using real-time polymerase chain reaction amplification. There was no significant difference in the distribution of allele and genotype frequencies among patients and healthy individuals. Moreover, none of the tag SNPs were associated either to T1DM age of onset or to the insurgence of APSIII. However, since the FYB protein is a key component in T cell response, its gene variants might play a role in protein function, which might be testable in a population with different genetic backgrounds or by using functional assays.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalGenetics and Molecular Research
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 15 2015

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Keywords

  • Autoimmune polyglandular syndrome type III
  • Fyn-binding protein
  • Polymorphisms
  • T1DM

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

Addobbati, C. J. C., Addobbati, C. J. C., de AzevêDo Silva, J., Tavares, N. A. C., Araújo, J., Guimarães, R. L., Guimarães, R. L., Brandão, L., Brandão, L., Crovella, S., Crovella, S., Sandrin-Garcia, P., & Sandrin-Garcia, P. (2015). FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III. Genetics and Molecular Research, 14(1), 29-33. https://doi.org/10.4238/2015.January.15.4