G(γ), A(γ) and β globin chain synthesis has been investigated in the peripheral blood and bone marrow from eight β-thalassaemia homozygotes. In five of eight cases total γ chain synthesis was higher in the peripheral blood than in the bone marrow; in seven out of eight cases Aγ chain synthesis was markedly higher in the marrow than in the peripheral blood. These data suggest that ineffective erythropoiesis selects F-cells synthesizing the largest amounts of G(γ) chains, while A(γ) producing cells are preferentially destroyed in the marrow.
|Number of pages||7|
|Journal||British Journal of Haematology|
|Publication status||Published - 1982|
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