G(γ) and A(γ) globin chain synthesis in bone marrow and peripheral blood of β-thalassaemia homozygotes

G. Saglio, C. Camaschella, A. Guerrasio

Research output: Contribution to journalArticle

Abstract

G(γ), A(γ) and β globin chain synthesis has been investigated in the peripheral blood and bone marrow from eight β-thalassaemia homozygotes. In five of eight cases total γ chain synthesis was higher in the peripheral blood than in the bone marrow; in seven out of eight cases Aγ chain synthesis was markedly higher in the marrow than in the peripheral blood. These data suggest that ineffective erythropoiesis selects F-cells synthesizing the largest amounts of G(γ) chains, while A(γ) producing cells are preferentially destroyed in the marrow.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalBritish Journal of Haematology
Volume52
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Hematology

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