G × e interaction and neurodevelopment II. Focus on adversities in paediatric depression: The moderating role of serotonin transporter

M. Bellani, M. Nobile, V. Bianchi, J. Van Os, P. Brambilla

Research output: Contribution to journalArticle


In a short series of articles, we will review the evidence for genotype by environment interaction (G × E) in developmental psychopathology. We will focus specifically on the characteristics of types of exposure assessed with respect to both their methods and findings. This article aims to review the studies exploring the moderating role of serotonin transporter on the effect of environmental adversities over time, particularly during childhood and adolescence, which is when level of internalizing symptoms and prevalence of mood disorders change substantially. Environmental adversities will not include abuse and maltreatment that have been reviewed before (see Bellani et al. 2012) and child's broader social ecology that will be reviewed in the next section.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalEpidemiology and Psychiatric Sciences
Issue number1
Publication statusPublished - Mar 2013



  • Child abuse
  • genetics
  • maltreatment
  • psychopathology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this