G-protein-coupled receptor kinases in cardiovascular conditions: Focus on G-protein-coupled receptor kinase 2, a gain in translational medicine

Alfonso Campanile, Guido Iaccarino

Research output: Contribution to journalArticle

Abstract

With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupled receptor kinases. This class of protein is indispensable for terminating signaling of G-protein-coupled receptors through receptor desensitization and downregulation. This article attempts to assemble the currently available information regarding G-protein-coupled receptor kinases and their role in cardiovascular disease and, in particular, the potential employment of G-protein-coupled receptor kinase 2 as biomarker of cardiac dysfunction.

Original languageEnglish
Pages (from-to)525-540
Number of pages16
JournalBiomarkers in Medicine
Volume3
Issue number5
DOIs
Publication statusPublished - 2009

Fingerprint

G-Protein-Coupled Receptor Kinase 2
G-Protein-Coupled Receptor Kinases
Translational Medical Research
G-Protein-Coupled Receptors
Medicine
Cardiovascular Diseases
Physiology
Biomarkers
Proteins
Down-Regulation

Keywords

  • βARKct
  • Chronic adrenergic activation
  • G-protein-coupled receptor kinases
  • GPCR desensitization
  • GPCR downregulation
  • GRK2 ablation
  • GRK2 upregulation
  • Lymphocyte β-adrenergic signaling

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

Cite this

G-protein-coupled receptor kinases in cardiovascular conditions : Focus on G-protein-coupled receptor kinase 2, a gain in translational medicine. / Campanile, Alfonso; Iaccarino, Guido.

In: Biomarkers in Medicine, Vol. 3, No. 5, 2009, p. 525-540.

Research output: Contribution to journalArticle

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