G protein oncogenes in pituitary tumors

Anna Spada, Lucia Vallar, Giovanni Faglia

Research output: Contribution to journalArticlepeer-review


G proteins are involved in the transduction of external signals from cell surface receptors to intracellular effectors. Somatic mutations activating the a-subunit of Gs (the stimulatory regulatory protein of adenylyl cyclase) by inhibiting its intrinsic GTPase activity have been first identified in human GH-secreting adenomas and subsequently found in thyroid tumors and in McCune-Albright syndrome. It has been therefore proposed that the gene encoding the GS a-subunit may be converted into an oncogene (gsp for GS protein) in cell types that proliferate in response to cAMP. Since several G proteins mediate signaling pathways that are effective in coupling external stimuli to cell proliferation, it appears most likely that in the near future other G protein oncogenes will be identified in human tumors.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number10
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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