Ga-68 dOTATOC PET, endoscopic ultrasonography, and multidetector CT in the diagnosis of duodenopancreatic neuroendocrine tumors: A single-centre retrospective study

Annibale Versari, Lorenzo Camellini, Gabriele Carlinfante, Andrea Frasoldati, Franco Nicoli, Elisa Grassi, Carmine Gallo, Francesca P. Giunta, Alessandro Fraternali, Diana Salvo, Mattia Asti, Francesco Azzolini, Veronica Iori, Romano Sassatelli

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience with use of these methods in patients suspected to have duodenopancreatic primitive NET. Methods: Nineteen consecutive patients (mean age, 56; 21-80), who underwent both Ga-68 DOTATOC PET/CT and EUS between March 2007 and November 2008 were retrospectively included in the study (16 underwent MDCT). Suspicion of NET was confirmed by EUS-FNA and/or surgery. Operative characteristics of PET, EUS, and MDCT were compared. Results: Twenty-three neuroendocrine lesions were diagnosed in 13/19 patients. EUS, PET, and MDCT correctly identified as affected 13/13 (100%), 12/13 (92%), and 10/11 (91%) patients, respectively. On a lesion basis, EUS, PET, and MDCT identified correctly as NETs 22/23 (96%), 20/23 (87%), and 13/18 (72%) lesions (P = 0.08 EUS vs. CT). Both on a patient and on a lesion basis, specificity was 67%, 83%, and 80% for EUS, PET, and MDCT, respectively. Conclusions: EUS, Ga-68 DOTATOC PET, and MDCT seem to have comparable accuracy in diagnosis of duodenopancreatic NET and their combination may allow an optimal preoperative diagnosis.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalClinical Nuclear Medicine
Volume35
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • And sensibility
  • Biopsy
  • Endosonography
  • Fine needle
  • Neuroendocrine tumors
  • Positron-emission tomography
  • Sensitivity
  • Tomography
  • X-ray computed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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