Ga-68 dOTATOC PET, endoscopic ultrasonography, and multidetector CT in the diagnosis of duodenopancreatic neuroendocrine tumors: A single-centre retrospective study

Annibale Versari, Lorenzo Camellini, Gabriele Carlinfante, Andrea Frasoldati, Franco Nicoli, Elisa Grassi, Carmine Gallo, Francesca P. Giunta, Alessandro Fraternali, Diana Salvo, Mattia Asti, Francesco Azzolini, Veronica Iori, Romano Sassatelli

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Abstract

Purpose: In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience with use of these methods in patients suspected to have duodenopancreatic primitive NET. Methods: Nineteen consecutive patients (mean age, 56; 21-80), who underwent both Ga-68 DOTATOC PET/CT and EUS between March 2007 and November 2008 were retrospectively included in the study (16 underwent MDCT). Suspicion of NET was confirmed by EUS-FNA and/or surgery. Operative characteristics of PET, EUS, and MDCT were compared. Results: Twenty-three neuroendocrine lesions were diagnosed in 13/19 patients. EUS, PET, and MDCT correctly identified as affected 13/13 (100%), 12/13 (92%), and 10/11 (91%) patients, respectively. On a lesion basis, EUS, PET, and MDCT identified correctly as NETs 22/23 (96%), 20/23 (87%), and 13/18 (72%) lesions (P = 0.08 EUS vs. CT). Both on a patient and on a lesion basis, specificity was 67%, 83%, and 80% for EUS, PET, and MDCT, respectively. Conclusions: EUS, Ga-68 DOTATOC PET, and MDCT seem to have comparable accuracy in diagnosis of duodenopancreatic NET and their combination may allow an optimal preoperative diagnosis.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalClinical Nuclear Medicine
Volume35
Issue number5
DOIs
Publication statusPublished - May 2010

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Endosonography
Neuroendocrine Tumors
Retrospective Studies

Keywords

  • And sensibility
  • Biopsy
  • Endosonography
  • Fine needle
  • Neuroendocrine tumors
  • Positron-emission tomography
  • Sensitivity
  • Tomography
  • X-ray computed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Ga-68 dOTATOC PET, endoscopic ultrasonography, and multidetector CT in the diagnosis of duodenopancreatic neuroendocrine tumors : A single-centre retrospective study. / Versari, Annibale; Camellini, Lorenzo; Carlinfante, Gabriele; Frasoldati, Andrea; Nicoli, Franco; Grassi, Elisa; Gallo, Carmine; Giunta, Francesca P.; Fraternali, Alessandro; Salvo, Diana; Asti, Mattia; Azzolini, Francesco; Iori, Veronica; Sassatelli, Romano.

In: Clinical Nuclear Medicine, Vol. 35, No. 5, 05.2010, p. 321-328.

Research output: Contribution to journalArticle

Versari, Annibale ; Camellini, Lorenzo ; Carlinfante, Gabriele ; Frasoldati, Andrea ; Nicoli, Franco ; Grassi, Elisa ; Gallo, Carmine ; Giunta, Francesca P. ; Fraternali, Alessandro ; Salvo, Diana ; Asti, Mattia ; Azzolini, Francesco ; Iori, Veronica ; Sassatelli, Romano. / Ga-68 dOTATOC PET, endoscopic ultrasonography, and multidetector CT in the diagnosis of duodenopancreatic neuroendocrine tumors : A single-centre retrospective study. In: Clinical Nuclear Medicine. 2010 ; Vol. 35, No. 5. pp. 321-328.
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abstract = "Purpose: In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience with use of these methods in patients suspected to have duodenopancreatic primitive NET. Methods: Nineteen consecutive patients (mean age, 56; 21-80), who underwent both Ga-68 DOTATOC PET/CT and EUS between March 2007 and November 2008 were retrospectively included in the study (16 underwent MDCT). Suspicion of NET was confirmed by EUS-FNA and/or surgery. Operative characteristics of PET, EUS, and MDCT were compared. Results: Twenty-three neuroendocrine lesions were diagnosed in 13/19 patients. EUS, PET, and MDCT correctly identified as affected 13/13 (100{\%}), 12/13 (92{\%}), and 10/11 (91{\%}) patients, respectively. On a lesion basis, EUS, PET, and MDCT identified correctly as NETs 22/23 (96{\%}), 20/23 (87{\%}), and 13/18 (72{\%}) lesions (P = 0.08 EUS vs. CT). Both on a patient and on a lesion basis, specificity was 67{\%}, 83{\%}, and 80{\%} for EUS, PET, and MDCT, respectively. Conclusions: EUS, Ga-68 DOTATOC PET, and MDCT seem to have comparable accuracy in diagnosis of duodenopancreatic NET and their combination may allow an optimal preoperative diagnosis.",
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T1 - Ga-68 dOTATOC PET, endoscopic ultrasonography, and multidetector CT in the diagnosis of duodenopancreatic neuroendocrine tumors

T2 - A single-centre retrospective study

AU - Versari, Annibale

AU - Camellini, Lorenzo

AU - Carlinfante, Gabriele

AU - Frasoldati, Andrea

AU - Nicoli, Franco

AU - Grassi, Elisa

AU - Gallo, Carmine

AU - Giunta, Francesca P.

AU - Fraternali, Alessandro

AU - Salvo, Diana

AU - Asti, Mattia

AU - Azzolini, Francesco

AU - Iori, Veronica

AU - Sassatelli, Romano

PY - 2010/5

Y1 - 2010/5

N2 - Purpose: In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience with use of these methods in patients suspected to have duodenopancreatic primitive NET. Methods: Nineteen consecutive patients (mean age, 56; 21-80), who underwent both Ga-68 DOTATOC PET/CT and EUS between March 2007 and November 2008 were retrospectively included in the study (16 underwent MDCT). Suspicion of NET was confirmed by EUS-FNA and/or surgery. Operative characteristics of PET, EUS, and MDCT were compared. Results: Twenty-three neuroendocrine lesions were diagnosed in 13/19 patients. EUS, PET, and MDCT correctly identified as affected 13/13 (100%), 12/13 (92%), and 10/11 (91%) patients, respectively. On a lesion basis, EUS, PET, and MDCT identified correctly as NETs 22/23 (96%), 20/23 (87%), and 13/18 (72%) lesions (P = 0.08 EUS vs. CT). Both on a patient and on a lesion basis, specificity was 67%, 83%, and 80% for EUS, PET, and MDCT, respectively. Conclusions: EUS, Ga-68 DOTATOC PET, and MDCT seem to have comparable accuracy in diagnosis of duodenopancreatic NET and their combination may allow an optimal preoperative diagnosis.

AB - Purpose: In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience with use of these methods in patients suspected to have duodenopancreatic primitive NET. Methods: Nineteen consecutive patients (mean age, 56; 21-80), who underwent both Ga-68 DOTATOC PET/CT and EUS between March 2007 and November 2008 were retrospectively included in the study (16 underwent MDCT). Suspicion of NET was confirmed by EUS-FNA and/or surgery. Operative characteristics of PET, EUS, and MDCT were compared. Results: Twenty-three neuroendocrine lesions were diagnosed in 13/19 patients. EUS, PET, and MDCT correctly identified as affected 13/13 (100%), 12/13 (92%), and 10/11 (91%) patients, respectively. On a lesion basis, EUS, PET, and MDCT identified correctly as NETs 22/23 (96%), 20/23 (87%), and 13/18 (72%) lesions (P = 0.08 EUS vs. CT). Both on a patient and on a lesion basis, specificity was 67%, 83%, and 80% for EUS, PET, and MDCT, respectively. Conclusions: EUS, Ga-68 DOTATOC PET, and MDCT seem to have comparable accuracy in diagnosis of duodenopancreatic NET and their combination may allow an optimal preoperative diagnosis.

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KW - Biopsy

KW - Endosonography

KW - Fine needle

KW - Neuroendocrine tumors

KW - Positron-emission tomography

KW - Sensitivity

KW - Tomography

KW - X-ray computed

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