Gaba and epilepsy: A study on thin hippocampus slices in vitro

Research output: Contribution to journalArticle

Abstract

Slices prepared from rat hippocampus were incubated in a special purpose chamber which allows intracellular recording from single CA 1 pyramidal neurons. The experiments have confirmed the crucial role of GABA-mediated inhibition in preventing excessive depolarizing shift leading to epileptogenesis in the hippocampus. Benzodiazepines enhance GABA activity, thus contributing to counteract hyperexcitability phenomena. However, according to the present results, their effects on membrane resistance can, only in part, be attributed to a modulation of GABA-chloride coupling. The significance of an early, bicuculline-insensitive, component of benzodiazepine activity, possibly involving ionic currents other than the chloride one, is discussed.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalActa Neurologica
Volume40
Issue number3-4
Publication statusPublished - 1985

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gamma-Aminobutyric Acid
Epilepsy
Hippocampus
Benzodiazepines
Chlorides
Bicuculline
Pyramidal Cells
Membranes
In Vitro Techniques

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Gaba and epilepsy : A study on thin hippocampus slices in vitro. / Avanzini, G.; De Curtis, M.; Franceschetti, S.; Frassoni, C.

In: Acta Neurologica, Vol. 40, No. 3-4, 1985, p. 191-199.

Research output: Contribution to journalArticle

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