Gaba and epilepsy: A study on thin hippocampus slices in vitro

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Slices prepared from rat hippocampus were incubated in a special purpose chamber which allows intracellular recording from single CA 1 pyramidal neurons. The experiments have confirmed the crucial role of GABA-mediated inhibition in preventing excessive depolarizing shift leading to epileptogenesis in the hippocampus. Benzodiazepines enhance GABA activity, thus contributing to counteract hyperexcitability phenomena. However, according to the present results, their effects on membrane resistance can, only in part, be attributed to a modulation of GABA-chloride coupling. The significance of an early, bicuculline-insensitive, component of benzodiazepine activity, possibly involving ionic currents other than the chloride one, is discussed.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalActa Neurologica
Issue number3-4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Clinical Neurology


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