GABA depolarizes neurons in the rat striatum: An in vivo study

N. B. Mercuri, P. Calabresi, A. Stefani, F. Stratta, G. Bernardi

Research output: Contribution to journalArticlepeer-review


GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
Issue number1
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Pharmacology


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