Abstract
GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.
| Original language | English |
|---|---|
| Pages (from-to) | 38-40 |
| Number of pages | 3 |
| Journal | Synapse |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - 1991 |
Fingerprint
ASJC Scopus subject areas
- Physiology
- Neuroscience(all)
- Pharmacology
Cite this
Mercuri, N. B., Calabresi, P., Stefani, A., Stratta, F., & Bernardi, G. (1991). GABA depolarizes neurons in the rat striatum: An in vivo study. Synapse, 8(1), 38-40.