GABA depolarizes neurons in the rat striatum: An in vivo study

N. B. Mercuri; P. Calabresi; A. Stefani; F. Stratta; G. Bernardi

GABA depolarizes neurons in the rat striatum: An in vivo study

N. B. Mercuri, P. Calabresi, A. Stefani, F. Stratta, G. Bernardi

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Synapse
Volume	8
Issue number	1
Publication status	Published - 1991

ASJC Scopus subject areas

Physiology
Neuroscience(all)
Pharmacology

Cite this

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abstract = "GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.",

author = "Mercuri, {N. B.} and P. Calabresi and A. Stefani and F. Stratta and G. Bernardi",

year = "1991",

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AU - Mercuri, N. B.

AU - Calabresi, P.

AU - Stefani, A.

AU - Stratta, F.

AU - Bernardi, G.

PY - 1991

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N2 - GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.

AB - GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.

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GABA depolarizes neurons in the rat striatum: An in vivo study

Abstract

ASJC Scopus subject areas

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