Abstract
GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.
Original language | English |
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Pages (from-to) | 38-40 |
Number of pages | 3 |
Journal | Synapse |
Volume | 8 |
Issue number | 1 |
Publication status | Published - 1991 |
ASJC Scopus subject areas
- Physiology
- Neuroscience(all)
- Pharmacology