GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders

A. Serretti, F. Macciardi, C. Cusin, E. Lattuada, R. Lilli, D. Di Bella, M. Catalano, E. Smeraldi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalPsychiatric Genetics
Volume8
Issue number4
Publication statusPublished - 1998

Fingerprint

Mood Disorders
gamma-Aminobutyric Acid
Genes
Aminobutyrates
Mental Disorders
Neurotransmitter Agents
Inpatients
Depression
Polymerase Chain Reaction

Keywords

  • Bipolar disorder
  • GABRA1
  • Mood disorder
  • Phenotype
  • Psychiatric genetic
  • Unipolar disorder

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Serretti, A., Macciardi, F., Cusin, C., Lattuada, E., Lilli, R., Di Bella, D., ... Smeraldi, E. (1998). GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. Psychiatric Genetics, 8(4), 251-254.

GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. / Serretti, A.; Macciardi, F.; Cusin, C.; Lattuada, E.; Lilli, R.; Di Bella, D.; Catalano, M.; Smeraldi, E.

In: Psychiatric Genetics, Vol. 8, No. 4, 1998, p. 251-254.

Research output: Contribution to journalArticle

Serretti, A, Macciardi, F, Cusin, C, Lattuada, E, Lilli, R, Di Bella, D, Catalano, M & Smeraldi, E 1998, 'GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders', Psychiatric Genetics, vol. 8, no. 4, pp. 251-254.
Serretti A, Macciardi F, Cusin C, Lattuada E, Lilli R, Di Bella D et al. GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. Psychiatric Genetics. 1998;8(4):251-254.
Serretti, A. ; Macciardi, F. ; Cusin, C. ; Lattuada, E. ; Lilli, R. ; Di Bella, D. ; Catalano, M. ; Smeraldi, E. / GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. In: Psychiatric Genetics. 1998 ; Vol. 8, No. 4. pp. 251-254.
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