GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders

A. Serretti; F. Macciardi; C. Cusin; E. Lattuada; R. Lilli; D. Di Bella; M. Catalano; E. Smeraldi

GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders

A. Serretti, F. Macciardi, C. Cusin, E. Lattuada, R. Lilli, D. Di Bella, M. Catalano, E. Smeraldi

Research output: Contribution to journal › Article › peer-review

Abstract

Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	Psychiatric Genetics
Volume	8
Issue number	4
Publication status	Published - 1998

Keywords

Bipolar disorder
GABRA1
Mood disorder
Phenotype
Psychiatric genetic
Unipolar disorder

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Genetics
Neuroscience(all)

Cite this

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title = "GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders",

abstract = "Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.",

keywords = "Bipolar disorder, GABRA1, Mood disorder, Phenotype, Psychiatric genetic, Unipolar disorder",

author = "A. Serretti and F. Macciardi and C. Cusin and E. Lattuada and R. Lilli and {Di Bella}, D. and M. Catalano and E. Smeraldi",

year = "1998",

language = "English",

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journal = "Psychiatric Genetics",

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T1 - GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders

AU - Serretti, A.

AU - Macciardi, F.

AU - Cusin, C.

AU - Lattuada, E.

AU - Lilli, R.

AU - Di Bella, D.

AU - Catalano, M.

AU - Smeraldi, E.

PY - 1998

Y1 - 1998

N2 - Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.

AB - Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.

KW - Bipolar disorder

KW - GABRA1

KW - Mood disorder

KW - Phenotype

KW - Psychiatric genetic

KW - Unipolar disorder

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JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 4

ER -

GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders

Abstract

Keywords

ASJC Scopus subject areas

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