GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders

A. Serretti, F. Macciardi, C. Cusin, E. Lattuada, R. Lilli, D. Di Bella, M. Catalano, E. Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalPsychiatric Genetics
Volume8
Issue number4
Publication statusPublished - 1998

Keywords

  • Bipolar disorder
  • GABRA1
  • Mood disorder
  • Phenotype
  • Psychiatric genetic
  • Unipolar disorder

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

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