Abstract
Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 251-254 |
| Number of pages | 4 |
| Journal | Psychiatric Genetics |
| Volume | 8 |
| Issue number | 4 |
| Publication status | Published - 1998 |
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Keywords
- Bipolar disorder
- GABRA1
- Mood disorder
- Phenotype
- Psychiatric genetic
- Unipolar disorder
ASJC Scopus subject areas
- Genetics(clinical)
- Psychiatry and Mental health
- Genetics
- Neuroscience(all)
Cite this
GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. / Serretti, A.; Macciardi, F.; Cusin, C.; Lattuada, E.; Lilli, R.; Di Bella, D.; Catalano, M.; Smeraldi, E.
In: Psychiatric Genetics, Vol. 8, No. 4, 1998, p. 251-254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GABA(A) alpha-1 subunit gene not associated with depressive symptomatology in mood disorders
AU - Serretti, A.
AU - Macciardi, F.
AU - Cusin, C.
AU - Lattuada, E.
AU - Lilli, R.
AU - Di Bella, D.
AU - Catalano, M.
AU - Smeraldi, E.
PY - 1998
Y1 - 1998
N2 - Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.
AB - Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders. In this study, we investigated the possibility that the gene for the γ-aminobutyric acid type A (GABA(A)) receptor alpha-1 subunit (GABRA1) might be associated with depressive symptomatology in a sample of mood disorder subjects. Sixty-seven inpatients affected by unipolar (n = 37) and bipolar (n = 30) disorder (DSMIV) were assessed at admission by the Hamilton depression rating scale (HAMD) and were typed using polymerase chain reaction (PCR) techniques. GABRA1 variants were not associated with depressive symptomatology, and consideration of possible stratification effects such as sex, psychiatric diagnosis and illness severity did not reveal any association either. GABA(A) alpha-1 subunit gene is not, therefore, associated with depressive symptomatology in mood disorder subjects.
KW - Bipolar disorder
KW - GABRA1
KW - Mood disorder
KW - Phenotype
KW - Psychiatric genetic
KW - Unipolar disorder
UR - http://www.scopus.com/inward/record.url?scp=0031593791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031593791&partnerID=8YFLogxK
M3 - Article
C2 - 9861645
AN - SCOPUS:0031593791
VL - 8
SP - 251
EP - 254
JO - Psychiatric Genetics
JF - Psychiatric Genetics
SN - 0955-8829
IS - 4
ER -