GABAB receptors in Schwann cells influence proliferation and myelin protein expression

Valerio Magnaghi, Marinella Ballabio, Ilaria T R Cavarretta, Wolfgang Froestl, Jeremy J. Lambert, Ileana Zucchi, Roberto C. Melcangi

Research output: Contribution to journalArticle

Abstract

The location and the role of γ-aminobutyric acid type B (GABA B) receptors in the central nervous system have recently received considerable attention, whilst relatively little is known regarding the peripheral nervous system. In this regard, here we demonstrate for the first time that GABAB receptor isoforms [i.e. GABAB(1) and GABAB(2)] are specifically localized in the rat Schwann cell population of the sciatic nerve. Using the selective GABAB agonist [i.e. (-)-baclofen] and the antagonists (i.e. CGP 62349, CGP 56999 A, CGP 55845 A), such receptors are shown to be functionally active and negatively coupled to the adenylate cyclase system. Furthermore, exposure of cultured Schwann cells to (-)-baclofen inhibits their proliferation and reduces the synthesis of specific myelin proteins (i.e. glycoprotein Po, peripheral myelin protein 22, myelin-associated glycoprotein, connexin 32), providing evidence for a physiological role of GABAB receptors in the glial cells of the peripheral nervous system.

Original languageEnglish
Pages (from-to)2641-2649
Number of pages9
JournalEuropean Journal of Neuroscience
Volume19
Issue number10
DOIs
Publication statusPublished - May 2004

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Keywords

  • GABA receptors
  • Myelin
  • Peripheral glia
  • Rat
  • Sciatic nerve

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Magnaghi, V., Ballabio, M., Cavarretta, I. T. R., Froestl, W., Lambert, J. J., Zucchi, I., & Melcangi, R. C. (2004). GABAB receptors in Schwann cells influence proliferation and myelin protein expression. European Journal of Neuroscience, 19(10), 2641-2649. https://doi.org/10.1111/j.0953-816X.2004.03368.x