GABAergic networks jump-start focal seizures

Marco De Curtis, Massimo Avoli

Research output: Contribution to journalArticle

Abstract

Abnormally enhanced glutamatergic excitation is commonly believed to mark the onset of a focal seizure. This notion, however, is not supported by firm evidence, and it will be challenged here. A general reduction of unit firing has been indeed observed in association with low-voltage fast activity at the onset of seizures recorded during presurgical intracranial monitoring in patients with focal, drug-resistant epilepsies. Moreover, focal seizures in animal models start with increased γ-aminobutyric acid (GABA)ergic interneuronal activity that silences principal cells. In vitro studies have shown that synchronous activation of GABAA receptors occurs at seizure onset and causes sizeable elevations in extracellular potassium, thus facilitating neuronal recruitment and seizure progression. A paradoxical involvement of GABAergic networks is required for the initiation of focal seizures characterized by low-voltage fast activity, which represents the most common seizure-onset pattern in focal epilepsies.

Original languageEnglish
Pages (from-to)679-687
Number of pages9
JournalEpilepsia
Volume57
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Seizures
Aminobutyrates
Partial Epilepsy
Physiologic Monitoring
GABA-A Receptors
gamma-Aminobutyric Acid
Potassium
Animal Models

Keywords

  • Focal seizures
  • GABA
  • Ictogenesis
  • Inhibitory networks

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

GABAergic networks jump-start focal seizures. / De Curtis, Marco; Avoli, Massimo.

In: Epilepsia, Vol. 57, No. 5, 01.05.2016, p. 679-687.

Research output: Contribution to journalArticle

De Curtis, Marco ; Avoli, Massimo. / GABAergic networks jump-start focal seizures. In: Epilepsia. 2016 ; Vol. 57, No. 5. pp. 679-687.
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