Gabapentin affects the expression of inflammatory mediators on healthy gingival cells

Valentina Candotto, Luca Scapoli, Rosa Maria Gaudio, Aldo Bruno Gianni, Alessandro Bolzoni, Pierpaolo Racco, Dorina Lauritano, Francesca Cura

Research output: Contribution to journalArticlepeer-review


Gabapentin is one of the most used drugs to treat postoperative pain with antihyperalgesic properties and has a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that the perioperative use of gabapentin reduces postoperative pain. In our study, fragments of gingival tissue of healthy volunteers were collected during operation. Gene expression of 29 genes was investigated in gingival fibroblasts cell culture treated with gabapentin, compared with untreated cells. Of the different chemokines and interleukins studied, only 10 were statistically significant (CCL1, CCR1, CCR4, CCR5, CCR6, ILI1A, ILI1B, IL5, IL6R, TNFSF10). The overexpression of these cytokines, obtained in many studies, leads us to think that gabapentin can interact and cause post-inflammatory gingival hyperplasia, but, probably, in our study the gabapentin has not the same effect, because we used gingival fibroblasts of healthy people.

Original languageEnglish
Article number2058738419827765
JournalInternational Journal of Immunopathology and Pharmacology
Publication statusPublished - Jan 1 2019


  • fibroblasts
  • gabapentin
  • gingival overgrowth
  • inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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