Gain of 1q in pediatric myelodysplastic syndromes

Cristina Morerio, Annamaria Rapella, Elisa Tassano, Edoardo Lanino, Concetta Micalizzi, Cristina Rosanda, Claudio Panarello

Research output: Contribution to journalArticle

Abstract

The presence of acquired clonal cytogenetic abnormalities in hematopoietic cells is one of the diagnostic hallmarks of myelodysplastic syndromes (MDS). Such anomalies may help in defining prognostic groups. We analyzed eight pediatric MDS, and herein describe three new cases, one de novo and two therapy-related, presenting an unbalanced rearrangement of 1q: one of them resulted in a derivative chromosome 6 apparently identical to a previously described one. We also review all the cases of gain of 1q reported in de novo and therapy-related childhood MDS.

Original languageEnglish
Pages (from-to)1437-1441
Number of pages5
JournalLeukemia Research
Volume30
Issue number11
DOIs
Publication statusPublished - Nov 2006

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Keywords

  • Childhood myelodysplastic syndrome
  • Cytogenetic abnormalities
  • Gain of 1q
  • Prognostic groups

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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