Gain of 1q in pediatric myelodysplastic syndromes

Cristina Morerio; Annamaria Rapella; Elisa Tassano; Edoardo Lanino; Concetta Micalizzi; Cristina Rosanda; Claudio Panarello

doi:10.1016/j.leukres.2005.12.022

Gain of 1q in pediatric myelodysplastic syndromes

Cristina Morerio, Annamaria Rapella, Elisa Tassano, Edoardo Lanino, Concetta Micalizzi, Cristina Rosanda, Claudio Panarello

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The presence of acquired clonal cytogenetic abnormalities in hematopoietic cells is one of the diagnostic hallmarks of myelodysplastic syndromes (MDS). Such anomalies may help in defining prognostic groups. We analyzed eight pediatric MDS, and herein describe three new cases, one de novo and two therapy-related, presenting an unbalanced rearrangement of 1q: one of them resulted in a derivative chromosome 6 apparently identical to a previously described one. We also review all the cases of gain of 1q reported in de novo and therapy-related childhood MDS.

Original language	English
Pages (from-to)	1437-1441
Number of pages	5
Journal	Leukemia Research
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2005.12.022
Publication status	Published - Nov 2006

Keywords

Childhood myelodysplastic syndrome
Cytogenetic abnormalities
Gain of 1q
Prognostic groups

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/j.leukres.2005.12.022

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title = "Gain of 1q in pediatric myelodysplastic syndromes",

abstract = "The presence of acquired clonal cytogenetic abnormalities in hematopoietic cells is one of the diagnostic hallmarks of myelodysplastic syndromes (MDS). Such anomalies may help in defining prognostic groups. We analyzed eight pediatric MDS, and herein describe three new cases, one de novo and two therapy-related, presenting an unbalanced rearrangement of 1q: one of them resulted in a derivative chromosome 6 apparently identical to a previously described one. We also review all the cases of gain of 1q reported in de novo and therapy-related childhood MDS.",

keywords = "Childhood myelodysplastic syndrome, Cytogenetic abnormalities, Gain of 1q, Prognostic groups",

author = "Cristina Morerio and Annamaria Rapella and Elisa Tassano and Edoardo Lanino and Concetta Micalizzi and Cristina Rosanda and Claudio Panarello",

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T1 - Gain of 1q in pediatric myelodysplastic syndromes

AU - Morerio, Cristina

AU - Rapella, Annamaria

AU - Tassano, Elisa

AU - Lanino, Edoardo

AU - Micalizzi, Concetta

AU - Rosanda, Cristina

AU - Panarello, Claudio

PY - 2006/11

Y1 - 2006/11

N2 - The presence of acquired clonal cytogenetic abnormalities in hematopoietic cells is one of the diagnostic hallmarks of myelodysplastic syndromes (MDS). Such anomalies may help in defining prognostic groups. We analyzed eight pediatric MDS, and herein describe three new cases, one de novo and two therapy-related, presenting an unbalanced rearrangement of 1q: one of them resulted in a derivative chromosome 6 apparently identical to a previously described one. We also review all the cases of gain of 1q reported in de novo and therapy-related childhood MDS.

AB - The presence of acquired clonal cytogenetic abnormalities in hematopoietic cells is one of the diagnostic hallmarks of myelodysplastic syndromes (MDS). Such anomalies may help in defining prognostic groups. We analyzed eight pediatric MDS, and herein describe three new cases, one de novo and two therapy-related, presenting an unbalanced rearrangement of 1q: one of them resulted in a derivative chromosome 6 apparently identical to a previously described one. We also review all the cases of gain of 1q reported in de novo and therapy-related childhood MDS.

KW - Childhood myelodysplastic syndrome

KW - Cytogenetic abnormalities

KW - Gain of 1q

KW - Prognostic groups

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JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

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ER -

Gain of 1q in pediatric myelodysplastic syndromes

Abstract

Keywords

ASJC Scopus subject areas

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