Gait analysis and cerebral volumes in Down's syndrome

Chiara Rigoldi, Manuela Galli, Claudia Condoluci, Filippo Carducci, Paolo Onorati, Giorgio Albertini

Research output: Contribution to journalArticlepeer-review


The aim of this study was to look for a relationship between cerebral volumes computed using a voxel-based morphometry algorithm and walking patterns in individuals with Down's syndrome (DS), in order to investigate the origin of the motor problems in these subjects with a view to developing appropriate rehabilitation programmes. Nine children with DS underwent a gait analysis (GA) protocol that used a 3D motion analysis system, force plates and a video system, and magnetic resonance imaging (MRI). Analysis of GA graphs allowed a series of parameters to be defined and computed in order to quantify gait patterns. By combining some of the parameters it was possible to obtain a 3D description of gait in terms of distance from normal values. Finally, the results of cerebral volume analysis were compared with the gait patterns found. A strong relationship emerged between cerebellar vermis volume reduction and quality of gait and also between grey matter volume reduction of some cerebral areas and asymmetrical gait. An evaluation of high-level motor deficits, reflected in a lack or partial lack of proximal functions, is important in order to define a correct rehabilitation programme.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalFunctional Neurology
Issue number3
Publication statusPublished - 2009


  • Cerebral volumes
  • Down's syndrome
  • Gait analysis
  • Optimised voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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